(2,4,6-Trichloro-phenoxy)-acetic acid (1H-pyrrol-2-ylmethylene)-hydrazide Chemical Properties

Density 

1.50±0.1 g/cm3(Predicted)

storage temp. 

Inert atmosphere,2-8°C

solubility 

DMSO: soluble15mg/mL (clear solution)

pka

11.95±0.46(Predicted)

form 

powder

color 

white to beige

Stability:

Stable for 2 years from date of purchase as supplied. Solutions in DMSO, DMF or ethanol may be stored at -20° for up to 3 months.

Safety Information

Hazard Codes 

Xn

Risk Statements 

20/21/22-36/37/38

Safety Statements 

26

RIDADR 

UN 3077 9 / PGIII

WGK Germany 

3

(2,4,6-Trichloro-phenoxy)-acetic acid (1H-pyrrol-2-ylmethylene)-hydrazide Usage And Synthesis

Description

ML-239 is an inhibitor of cancer stem cells, displaying greater than 23-fold selective inhibition of a breast cancer stem cell-like cell line (EC₅₀ = 1.18 μM) over an isogenic control cell line (EC₅₀ = 27.6 μM). It is also toxic to the breast carcinoma cell line MDA-MB-231. ML-239 alters the expression of genes in the MAPK, NF-κB, and inflammatory cytokine pathways. It is stable in saline and modestly stable in human plasma.

Uses

ML-239, is an inhibitor of breast cancer stem cells, with greater than 23 fold selectivity of inhibition in the cell line.

Definition

ChEBI: N'-(2-pyrrolylidenemethyl)-2-(2,4,6-trichlorophenoxy)acetohydrazide is an aromatic ether.

storage

Store at +4°C

References

[1] LEIGH C. CARMODY . Phenotypic High-Throughput Screening Elucidates Target Pathway in Breast Cancer Stem Cell–Like Cells[J]. SLAS Discovery, 2012, 17 9: Pages 1204-1210. DOI:10.1177/1087057112458317
[2] ANDREW R. GERMAIN . Identification of a selective small molecule inhibitor of breast cancer stem cells[J]. Bioorganic & Medicinal Chemistry Letters, 2012, 22 10: Pages 3571-3574. DOI:10.1016/j.bmcl.2012.01.035
[3] MATTHEW G REES. Correlating chemical sensitivity and basal gene expression reveals mechanism of action[J]. Nature chemical biology, 2015, 12 2: 109-116. DOI:10.1038/nchembio.1986

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