ChemicalBook > Product Catalog > Organic Chemistry > Hydrocarbons and derivatives > 4-Chloro-N-(4-hydroxy-1-naphthalenyl)-3-nitro-benzenesulfonamide
4-Chloro-N-(4-hydroxy-1-naphthalenyl)-3-nitro-benzenesulfonamide
4-Chloro-N-(4-hydroxy-1-naphthalenyl)-3-nitro-benzenesulfonamide Basic information
- Product Name:
- 4-Chloro-N-(4-hydroxy-1-naphthalenyl)-3-nitro-benzenesulfonamide
- Synonyms:
-
- 4-Chloro-N-(4-hydroxy-1-naphthalenyl)-3-nitro-benzenesulfonamide
- SW155246
- Benzenesulfonamide, 4-chloro-N-(4-hydroxy-1-naphthalenyl)-3-nitro-
- SW155246 >=98% (HPLC)
- 4-chloro-N-(4-hydroxynaphthalen- 1-yl)-3-nitrobenzenesulfonamide
- SW 155246,cancer,hDNMT1,DNMTs,DNMT1 inhibitor,SW155246,Inhibitor,SW-155246,inhibit,mDNMT3A,DNA MTases,DNA Methyltransferase
- CAS:
- 420092-79-1
- MF:
- C16H11ClN2O5S
- MW:
- 378.79
- Mol File:
- 420092-79-1.mol
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4-Chloro-N-(4-hydroxy-1-naphthalenyl)-3-nitro-benzenesulfonamide Chemical Properties
- storage temp.
- 2-8°C
- solubility
- DMSO: soluble10mg/mL, clear
- form
- powder
- color
- white to light brown
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4-Chloro-N-(4-hydroxy-1-naphthalenyl)-3-nitro-benzenesulfonamide Usage And Synthesis
Description
SW155246 is an inhibitor of DNA methyltransferase 1 (DNMT1; IC50 = 1.2 μM). It is selective for human DNMT1 over murine DNMT3 (IC50 = 38 μM). SW155246 inhibits HeLa and A549 tumor cell growth in a redox-independent manner (IC50s = 8-20 μM). It also inhibits genomic methylation in HeLa cells when used at concentrations ranging from 10 to 18.6 μM.
4-Chloro-N-(4-hydroxy-1-naphthalenyl)-3-nitro-benzenesulfonamideSupplier
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