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4-Hydroxy-1-methyl-7-phenoxy-3-isoquinolinecarboxylic acid methyl ester

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4-Hydroxy-1-methyl-7-phenoxy-3-isoquinolinecarboxylic acid methyl ester Basic information

Product Name:
4-Hydroxy-1-methyl-7-phenoxy-3-isoquinolinecarboxylic acid methyl ester
Synonyms:
  • fg-4592 int 2
  • methyl 4-hydroxy-1-methyl-7-phenoxyisoquinoline-3-carboxylate
  • 1 - methyl - 4 - hydroxy - 7 - phenoxy isoquinoline - 3 - methyl formate
  • Fg-4592/FG4592 int 2
  • ROXA-019
  • 4-Hydroxy-1-methyl-7-phenoxy-3-isoquinolinecarboxylic acid methyl ester
  • methyl 4-hydroxy-1-methyl-7-pheno1-(2,6-difluorobenzyl)-1H-1,2,3-triazole-4-carboxylic acid xyisoquinoline-3-carboxylate
  • 3-Isoquinolinecarboxylic acid, 4-hydroxy-1-methyl-7-phenoxy-, methyl ester
CAS:
1421312-34-6
MF:
C18H15NO4
MW:
309.32
Product Categories:
  • API
Mol File:
1421312-34-6.mol
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4-Hydroxy-1-methyl-7-phenoxy-3-isoquinolinecarboxylic acid methyl ester Chemical Properties

Boiling point:
537.3±45.0 °C(Predicted)
Density 
1.289±0.06 g/cm3(Predicted)
storage temp. 
Inert atmosphere, 2-8°C
pka
6.24±0.50(Predicted)
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4-Hydroxy-1-methyl-7-phenoxy-3-isoquinolinecarboxylic acid methyl ester Usage And Synthesis

Uses

4-Hydroxy-1-methyl-7-phenoxy-methyl ester-3-isoquinolinecarboxylic Acid is used as a reagent in the preparation of Roxadustat (H948180), which is a drug used to treat anemia and chronic renal insufficiency.

Preparation

Add 25 g of glacial acetic acid solution containing methyl 1-((dimethylamino)methyl)-4-hydroxy-7-phenoxyisoquinolyl-3-carboxylate into a 1 L four-necked flask which contain 13 g Zinc powder. Then in a stirring state, add 7.5g of 5% dilute hydrochloric acid and raise the temperature to 50-60 ℃. When the raw materials in the liquid phase have basically reacted, reduce the temperature. Filter reaction solution.  Rotary evaporated the filtrate obtain 4-Hydroxy-1-methyl-7-phenoxy-3-isoquinolinecarboxylic acid methyl ester (purity: 96.9%, yield: 87.7%).

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4-Hydroxy-1-methyl-7-phenoxy-3-isoquinolinecarboxylic acid methyl ester(1421312-34-6)Related Product Information