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4-Trifluoromethoxyphenylboronic acid

Basic information Safety Supplier Related

4-Trifluoromethoxyphenylboronic acid Basic information

Product Name:
4-Trifluoromethoxyphenylboronic acid
Synonyms:
  • AKOS BRN-0136
  • 4-(TRIFLUOROMETHOXY)PHENYLBORONIC ACID
  • 4-(TRIFLUOROMETHOXY)BENZENEBORONIC ACID
  • P-TRIFLUOROMETHOXY BENZOBORIC ACID
  • P-(TRIFLUOROMETHOXY)PHENYLBORONIC ACID
  • RARECHEM AH PB 0078
  • 4-(Trifluoromethoxy)phenylboronicAcid(containsvaryingamountsofAnhydride)
  • 4-Trifluoromethoxyphenylboronic acid 4-(Trifluoromethoxy)benzeneboronic acid
CAS:
139301-27-2
MF:
C7H6BF3O3
MW:
205.93
EINECS:
000-000-0
Product Categories:
  • Aryl
  • Fluorinated
  • Organoborons
  • B (Classes of Boron Compounds)
  • Boronic Acids
  • Building Blocks for Liquid Crystals
  • Substituted Boronic Acids
  • Boronic Acid
  • Chalcones, etc. (Building Blocks for Liquid Crystals)
  • Functional Materials
  • Boronic Acids
  • Boronic Acids and Derivatives
  • Boronate Ester
  • Potassium Trifluoroborate
  • blocks
  • BoronicAcids
  • FluoroCompounds
  • Boronic Acid series
  • bc0001
Mol File:
139301-27-2.mol
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4-Trifluoromethoxyphenylboronic acid Chemical Properties

Melting point:
123-127 °C(lit.)
Boiling point:
256.6±50.0 °C(Predicted)
Density 
1.41±0.1 g/cm3(Predicted)
storage temp. 
Keep in dark place,Sealed in dry,Room Temperature
solubility 
soluble in Methanol
pka
8.29±0.10(Predicted)
form 
Crystalline Powder
color 
White to beige
BRN 
8548201
InChIKey
HUOFUOCSQCYFPW-UHFFFAOYSA-N
CAS DataBase Reference
139301-27-2(CAS DataBase Reference)
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Safety Information

Hazard Codes 
Xi,Xn
Risk Statements 
36/37/38-20/21/22
Safety Statements 
37/39-26-36
WGK Germany 
3
Hazard Note 
Irritant
HS Code 
29319090

MSDS

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4-Trifluoromethoxyphenylboronic acid Usage And Synthesis

Chemical Properties

white to beige crystalline powder

Uses

B-[4-(Trifluoromethoxy)phenyl]boronic Acid is a reagent used in the synthesis of orally bioavailable matrix metalloprotinase inhibitors. Also used in the preparation of chromen-4-one inhibitors used against DNA dependant protein kinases.

Application

4-Trifluoromethoxyphenylboronic acid can reactant involved in the synthesis of biologically active molecules including:
Lactate dehydrogenase inhibitors for use against cancer cell proliferation
Nitro-phenoxybenzoic acid derivatives for PAI-1 inhibition
PA-824 analogs for use as antituberculosis drugs
Modulators of survival motor neuron protein
Reactant involved in addition reactions and cross-coupling reactions including Suzuki-Miyaura cross-coupling

4-Trifluoromethoxyphenylboronic acidSupplier

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