ANTIPAIN HYDROCHLORIDE DIHYDRATE
ANTIPAIN HYDROCHLORIDE DIHYDRATE Basic information
- Product Name:
- ANTIPAIN HYDROCHLORIDE DIHYDRATE
- Synonyms:
-
- N2-[[(1-Carboxy-2-phenylethyl)amino]carbonyl]-L-arginyl-N-[4-[(aminoiminomethyl)amino]-1-formylbutyl]-L-valinamide
- PHE-ARG-VAL-ARG-CHO
- Antipain research grade
- 4-((aminoiminomethyl)amino)-1-formylbutyl)-
- ANTIPAIN HYDROCHLORIDE DIHYDRATE
- N2-[[(1-carboxyphenethyl)amino]carbonyl]-L-arginyl-N-[4-[(aminoiminomethyl)amino]-1-formylbutyl]-L-valinamide
- ANTIPAIN ~10000 U/MG
- Nα-[N2-[[(1-Carboxy-2-phenylethyl)amino]carbonyl]-L-arginyl]-N-[4-[(aminoiminomethyl)amino]-1-formylbutyl]-L-valinamide
- CAS:
- 37691-11-5
- MF:
- C27H44N10O6
- MW:
- 604.7
- EINECS:
- 253-631-0
- Product Categories:
-
- A - K
- Aldehydes
- Antibacterial
- Antibiotics A to Z
- Antibiotics
- Antibiotics A-F
- Antibiotics by Application
- Antineoplastic and Immunosuppressive Antibiotics
- Building Blocks
- C13-C60
- Carbonyl Compounds
- Chemical Structure Class
- Chemical Synthesis
- Inhibits an Enzyme
- Mechanism of Action
- Organic Building Blocks
- Peptides
- Spectrum of Activity
- Pepetides
- Mol File:
- 37691-11-5.mol
ANTIPAIN HYDROCHLORIDE DIHYDRATE Chemical Properties
- Density
- 1.38
- storage temp.
- −20°C
- pka
- 3.84±0.10(Predicted)
- Specific Activity
- >50000U/mg
- BRN
- 6837629
- InChIKey
- SDNYTAYICBFYFH-KTYMLHDXSA-N
- SMILES
- [H]C(=O)C(CCCNC(N)=N)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(N)=N)NC(=O)N[C@@H](Cc1ccccc1)C(O)=O)C(C)C
Safety Information
- WGK Germany
- 3
- RTECS
- YV9350700
- F
- 1-10
- Storage Class
- 11 - Combustible Solids
ANTIPAIN HYDROCHLORIDE DIHYDRATE Usage And Synthesis
Uses
Antipain is a reversible inhibitor of Ser and Cys proteases.
General Description
Chemical structure: peptide
Biochem/physiol Actions
Reversible inhibitor of serine/cysteine proteases and some trypsin-like serine proteases. Its action resembles leupeptin; however, its plasmin inhibition is less and its cathepsin A inhibition is more than that observed with leupeptin. Chronic administration can reduce the frequency of chemically induced transformation in BALB/c-/3T3 cells.
in vivo
The intact, cycling female mice received subcutaneous injections of Antipain (3 mg) for 16 days, their uteri shows significant diminution in weight and total DNA when compared to untreated controls[4].
Antipain (100 μg/g body wt; i.p.; at 12h intervals from 0 to 120 h or 240 to 360 h) shows inhibitory effect on Urethane-induced lung neoplasia in mice[5].
ANTIPAIN HYDROCHLORIDE DIHYDRATESupplier
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