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MOLLUGIN

Basic information Safety Supplier Related

MOLLUGIN Basic information

Product Name:
MOLLUGIN
Synonyms:
  • Rubimaillin
  • 2H-Naphtho[1,2-b]pyran-5-carboxylic acid
  • 6-hydroxy-2, 2-dimethyl-, methylester
  • 2,2-Dimethyl-6-hydroxy-2H-naphtho[1,2-b]pyran-5-carboxylic acid methyl ester
  • 6-Hydroxy-2,2-dimethyl-2H-naphtho[1,2-b]pyran-5-carboxylic acid methyl ester
  • MOLLUGIN
  • Methyl 6-hydroxy-2,2-dimethylbenzo[h]chromene-5-carboxylate
  • RUBIMAILLIN; MOLLUGIN
CAS:
55481-88-4
MF:
C17H16O4
MW:
284.31
EINECS:
683-209-5
Product Categories:
  • chemical reagent
  • pharmaceutical intermediate
  • reference substance
  • phytochemical
  • reference standards from Chinese medicinal herbs (TCM).
  • standardized herbal extract
Mol File:
55481-88-4.mol
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MOLLUGIN Chemical Properties

Melting point:
132~134℃
Boiling point:
453.2±45.0 °C(Predicted)
Density 
1.239±0.06 g/cm3(Predicted)
storage temp. 
2-8°C
solubility 
Chloroform (Slightly), Ethyl Acetate (Slightly)
form 
Solid
pka
8.40±0.40(Predicted)
color 
Yellow to Green
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Safety Information

Safety Statements 
24/25
HS Code 
29329990
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MOLLUGIN Usage And Synthesis

Uses

Mollugin is an anti-tumor agent inducing apoptosis and autophagy in various cancer models.

Definition

ChEBI: Rubimaillin is a benzochromene that is 2H-benzo[h]chromene which is substituted by two methyl groups at position 2, a methoxycarbonyl group at position 5, and a hydroxy group at position 6. Found in the Chinese medical plant Rubia cordifola, It has an anti-cancer effect by inhibition of TNF-alpha-induced NF-kappaB activation. It is also a dual inhibitor of acyl-CoA:cholesterol acyltransferase 1 and 2 (ACAT1 and ACAT2), but is more selective for the ACAT2 isozyme. It has a role as a plant metabolite, an acyl-CoA:cholesterol acyltransferase 2 inhibitor, a NF-kappaB inhibitor, an antineoplastic agent, an apoptosis inducer, a neuroprotective agent and an anti-inflammatory agent. It is a benzochromene, a methyl ester and a member of phenols.

MOLLUGINSupplier

Shaanxi Jianchuang Biotechnology Co., Ltd. Gold
Tel
13335389838
Email
3305337057@qq.com
Shanghai Winherb Medical Technology Co., Ltd. Gold
Tel
400-1865138 13341702378
Email
190129269@qq.com
Chembest Research Laboratories Limited
Tel
021-20908456
Email
sales@BioChemBest.com
BeiJing Hwrk Chemicals Limted
Tel
0757-86329057 18934348241
Email
sales4.gd@hwrkchemical.com
Adamas Reagent, Ltd.
Tel
400-6009262 16621234537
Email
zhangsn@titansci.com