MOLLUGIN Chemical Properties

Melting point:

132～134℃

Boiling point:

453.2±45.0 °C(Predicted)

Density 

1.239±0.06 g/cm3(Predicted)

storage temp. 

2-8°C

solubility 

Chloroform (Slightly), Ethyl Acetate (Slightly)

form 

Solid

pka

8.40±0.40(Predicted)

color 

Yellow to Green

Safety Information

Safety Statements 

24/25

HS Code 

29329990

MOLLUGIN Usage And Synthesis

Uses

Mollugin is an anti-tumor agent inducing apoptosis and autophagy in various cancer models.

Definition

ChEBI: Rubimaillin is a benzochromene that is 2H-benzo[h]chromene which is substituted by two methyl groups at position 2, a methoxycarbonyl group at position 5, and a hydroxy group at position 6. Found in the Chinese medical plant Rubia cordifola, It has an anti-cancer effect by inhibition of TNF-alpha-induced NF-kappaB activation. It is also a dual inhibitor of acyl-CoA:cholesterol acyltransferase 1 and 2 (ACAT1 and ACAT2), but is more selective for the ACAT2 isozyme. It has a role as a plant metabolite, an acyl-CoA:cholesterol acyltransferase 2 inhibitor, a NF-kappaB inhibitor, an antineoplastic agent, an apoptosis inducer, a neuroprotective agent and an anti-inflammatory agent. It is a benzochromene, a methyl ester and a member of phenols.

MOLLUGIN(55481-88-4)Related Product Information

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