Cholesteryl myristate Chemical Properties

Melting point:

84 °C

Boiling point:

589.77°C (rough estimate)

Density 

0.9309 (rough estimate)

refractive index 

1.5250 (estimate)

storage temp. 

Sealed in dry,2-8°C

solubility 

Chloroform (Slightly), Hexanes (Slightly)

form 

A crystalline solid

LogP

16.656 (est)

CAS DataBase Reference

1989-52-2(CAS DataBase Reference)

NIST Chemistry Reference

Cholesteryl myristate(1989-52-2)

EPA Substance Registry System

Cholest-5-en-3-ol (3.beta.)-, tetradecanoate (1989-52-2)

Safety Information

Hazard Codes 

Xi

Risk Statements 

36/37/38

Safety Statements 

26-36

WGK Germany 

3

MSDS

• Language:English Provider:[(3S,8S,9S,10R,13R,14S,17R)-10,13-Dimethyl-17-[(2R)-6-methylheptan-2-yl]-2,3,4,7,8,9,11,12,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-3-yl] tetradecanoate
• Language:English Provider:SigmaAldrich

Cholesteryl myristate Usage And Synthesis

Description

Cholesteryl myristate is a cholesterol ester. Levels of cholesteryl myristate are increased in the serum, liver, and aorta in rabbits fed a high-cholesterol diet and positively correlate with development of non-alcoholic fatty liver disease (NAFLD). Plasma levels of cholesteryl myristate also positively correlate with the presence of unstable atherosclerotic plaques in coronary artery disease. Cholesterol myristate has been used in the composition of lipid nanoparticles as drug carrier systems for drugs with low water solubility.

Uses

Cholesteryl Myristate is a natural steroid present in traditional Chinese medicine or used in tribal medicine.

Definition

ChEBI: A cholesterol ester obtained by the formal condensation of the hydroxy group of cholesterol with the carboxy group of myristic acid.

Purification Methods

Crystallise the myristate ester from Me2CO, EtOH/EtOAc or EtOH/Et2O or n-pentanol. Purify it also by column chromatography on silica gel and eluting with MeOH then evaporating to dryness. Recrystallise it and finally, dry it in vacuo over P2O5 and store it at -20o. [Labarière et al. Analyt Chem 30 1466 1958, Malanik & Malat Anal Chim Acta 76 464 1975, Beilstein 6 III 2638].

Cholesteryl myristate(1989-52-2)Related Product Information

• STIGMASTEROL
• Propylamine
• N,N-Dimethylformamide
• Xylene
• Dimethyl ether
• Dimethyl sulfoxide
• ETHANE
• LANOSTEROL
• Dimethyl phthalate
• Dimethyl sulfate
• [(3S,8S,10R,13R,14S,17R)-10,13-dimethyl-17-[(2R)-6-methylheptan-2-yl]-2,3,4,7,8,9,11,12,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-3-yl] 2,4-dichlorobenzoate
• Dimethyl carbonate
• Dimethyl fumarate
• Cholesterol
• Dacthal
• LUMISTEROL
• Phthalates
• CHOLESTERYL STEARATE