Budralazine Chemical Properties

Melting point:

183-185 °C(lit.)

Boiling point:

373.02°C (rough estimate)

Density 

1.1506 (rough estimate)

refractive index 

1.6000 (estimate)

storage temp. 

Amber Vial, -20°C Freezer, Under inert atmosphere

solubility 

Chloroform (Slightly), DMSO (Slightly), Methanol (Slightly, Heated)

form 

Solid

pka

9.54±0.70(Predicted)

color 

Light Yellow to Yellow

Stability:

Light Sensitive

CAS DataBase Reference

36798-79-5(CAS DataBase Reference)

Safety Information

Hazard Codes 

Xn

Risk Statements 

22

Safety Statements 

22-24/25

WGK Germany 

3

RTECS 

TH9185000

Toxicity

LD50 in mice, rats (mg/kg): 1820, 620 orally; 4020, 3570 i.p. (Onodera)

MSDS

• Language:English Provider:SigmaAldrich

Budralazine Usage And Synthesis

Description

Budralazine is an antihypertensive agent which is somewhat less potent than structurally related hydralazine, and reportedly produces less tachycardia.

Originator

Daiichi (Japan)

Uses

Budralazine a new antihypertensive agent. Budralazine is a direct-acting vasodilator.

Definition

ChEBI: Budralazine is a member of phthalazines.

Manufacturing Process

A mixture of 2.0 g of 1-hydrazinophthalazine hydrochloride, 1.1 g of mesityl oxide (isoproplyideneacetone) and 100 ml of ethanol, was refluxed for 3 hours. The reaction mixture was concentrated in vacuo and the residue was dissolved in water. The water solution was neutralized with sodium bicarbonate, salted out and the product was extracted with benzene. The benzene layer was passed through a comparatively short column of alumina and the solvent was removed. The residue was crystallized from ether to give 0.7 g of 1-(1,3-dimethyl-2-butenylidene) hydrazinophthalazine, melting point 131°-132°C.

brand name

BUTERAZINE

Therapeutic Function

Antihypertensive

Budralazine(36798-79-5)Related Product Information

• Maleic acid
• 2,6-DIMETHYLNAPHTHALENE
• DBU
• 1,2-Dimethylhydrazine Dihydrochloride
• ETHANE
• Dimethyl phthalate
• Dimethyl sulfide
• Dimethyl ether
• Polybutene
• CIS-BUTENEDIOIC ANHYDRIDE
• Fumaric acid
• Dimethyl fumarate
• Dimethyl sulfoxide
• N,N-Dimethylformamide
• 3-BUTENE-1,2-DIOL
• Phthalazine
• Chrysene
• 1,2H-PHTHALAZONE,PHTHALAZONE