CYCLOPROPANESULFINIC ACID, SODIUM SALT Chemical Properties

Melting point:

245-248°C

storage temp. 

Inert atmosphere,Room Temperature

Appearance

White to off-white Solid

InChI

InChI=1S/C3H6O2S.Na.H/c4-6(5)3-1-2-3;;/h3H,1-2H2,(H,4,5);;

InChIKey

UQDAMACUKOYMTP-UHFFFAOYSA-N

SMILES

S(C1CC1)(O)=O.[NaH]

CYCLOPROPANESULFINIC ACID, SODIUM SALT Usage And Synthesis

Uses

Sodium Cyclopropanesulfinate is a general chemical reagent used in the synthesis of AMG 232 (A576560), a potent MDM2-P53 inhibitor for use as an anti-tumor agent.

Synthesis

Sodium cyclopropyl sulfite was prepared as follows: sodium sulfite (1.32 g, 1.1 mmol), sodium bicarbonate (1.6 g, 20.0 mmol) was dissolved in pure water (15 mL), and the reaction was stirred at 55 ?? C for 10 min, then cyclopropylsulfonyl chloride (1.4 g, 10.0 mmol) was slowly added dropwise, and the reaction was stirred at 60 ?? C for 3 h. After the reaction was stirred at 60 ?? C for 3 h, the water was concentrated directly to dryness, and cyclopropylsulfinic acid (4 g) was obtained. sodium cyclopropylsulfonate (4 g).

CYCLOPROPANESULFINIC ACID, SODIUM SALT(910209-21-1)Related Product Information

• Disodium methanedisulfonate
• Cyclopropanecarboxylic acid
• Cyclopropanesulfonyl chloride
• Cyclopropanecarboxaldehyde
• Butyl Cyclopropanesulfonate
• Disodium nucleotide
• Sucralose
• Sodium erythorbate
• Sodium carboxymethyl cellulose
• Sodium difluoromethanesulfinate
• Sodium allylsulfonate
• Formaldehyde sodium bisulfite
• N/A
• Sodium methyl sulfinate
• CYCLOPROPANESULFINIC ACID, SODIUM SALT