MASTOPARAN Chemical Properties

Boiling point:

1676.8±65.0 °C(Predicted)

Density 

1.150±0.06 g/cm3(Predicted)

storage temp. 

−20°C

solubility 

H₂O: 1 mg/mL, clear, colorless

form 

White solid

pka

13.43±0.46(Predicted)

color 

white

BRN 

5491949

Sequence

H-Ile-Asn-Leu-Lys-Ala-Leu-Ala-Ala-Leu-Ala-Lys-Lys-Ile-Leu-NH2

Safety Information

Safety Statements 

22-24/25

WGK Germany 

3

F 

10

MSDS

• Language:English Provider:SigmaAldrich

MASTOPARAN Usage And Synthesis

Uses

Mastoparan has been used as a calmodulin antagonist.

Definition

ChEBI: A member of the class of mastopyrans that is a 14-amino acid polypeptide comprising isoleucyl, asparaginyl, leucyl, lysyl, alanyl, leucyl, alanyl, alanyl, leucyl, alanyl, lysyl, lysyl, isoleucyl, and leucinamide residues coupled in sequence. It is the majo active component of the venom of the vespid wasp, Vespula lewisii and causes degranulation of mast cells.

General Description

Mastoparan is a cationic, amphiphilic, tetradecapeptide amide. It is composed of the restricted amino acid and the repeated sequence. This protein is a nonspecific secretagogue isolated from venom of wasp.

Biochem/physiol Actions

Mastoparan effectively stimulates exocytosis from diverse mammalian cells. The encoded protein facilitates the secretion of histamine from mast cells, serotonin from platelets, catecholamines from chromaffin cells and prolactin from the anterior pituitary. In addition, it is also involved in activation of Phospholipase A2 and phosphoinositides (Pl) break down. Mastoparan functions as an inhibitor for calmodulin-stimulated phosphodiesterase. Mastoparan helps in mitochondrial permeability transition by enhancing an apparent bimodal mechanism of action.

MASTOPARAN(72093-21-1)Related Product Information

• syn-coll
• PAL-KTTKS
• MASTOPARAN 7 SYNTHETIC >98%,mastoparan from polistes jadwagae,MASTOPARAN 7
• mastoparan C
• mastoparan, des-Ile(1)-des-Asn(2)-
• MASTOPARAN 17 SYNTHETIC >97%,MASTOPARAN 17
• MASTOPARAN X
• eumenine mastoparan-AF
• MASTOPARAN, POLISTES,MASTOPARAN POLISTES JADWAGAE,POLISTES MASTOPARAN
• mastoparan, 11-dansyl-
• MASTOPARAN 8
• mastoparan B
• mastoparan M
• GALANIN (1-13)-MASTOPARAN
• MASTOPARAN