4-CHLORO-3-FLUOROPHENYLACETIC ACID Chemical Properties

Melting point:

88-91℃

Boiling point:

293.1±25.0 °C(Predicted)

Density 

1.417±0.06 g/cm3(Predicted)

storage temp. 

Sealed in dry,Room Temperature

pka

3.97±0.10(Predicted)

Appearance

White to off-white Solid

Safety Information

Hazard Codes 

Xi,E

Risk Statements 

36/37/38

Safety Statements 

26-36/37/39

Hazard Note 

Irritant

HS Code 

2916399090

4-CHLORO-3-FLUOROPHENYLACETIC ACID Usage And Synthesis

Synthesis

General procedure for the synthesis of 4-chloro-3-fluorophenylacetic acid from 3-fluoro-4-chlorophenylacetonitrile: A mixture of 3-fluoro-4-chlorophenylacetonitrile (7.8 g, 0.046 mol), water (7.5 mL), concentrated sulfuric acid (7.5 mL) and acetic acid (7.5 mL) was heated and refluxed for 2 hours. After the reaction was completed, the mixture was cooled to room temperature and then slowly poured into ice water. The precipitated solid product was collected by filtration and washed with ether to yield 4-chloro-3-fluorophenylacetic acid (6.8 g, 79% yield). The structure of the product was confirmed by 1H NMR (300 MHz, DMSO-d6): δ 3.64 (s, 2H), 7.14 (ddd, J = 0.6, 2.1, 8.2 Hz, 1H), 7.34 (dd, J = 2.1, 10.6 Hz, 1H), 7.52 (t, J = 8.1 Hz, 1H). Mass spectrum (ESI-) m/z: 187 [M-H]-.

References

[1] Patent: WO2010/31, 2010, A1. Location in patent: Page/Page column 55
[2] Patent: WO2010/32, 2010, A1. Location in patent: Page/Page column 54
[3] Patent: WO2010/30, 2010, A1. Location in patent: Page/Page column 48

4-CHLORO-3-FLUOROPHENYLACETIC ACID(883500-51-4)Related Product Information

• meperfluthrin
• 3-Fluorophenylacetic acid