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PARATHYROID HORMONE (1-34), RAT

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PARATHYROID HORMONE (1-34), RAT Basic information

Product Name:
PARATHYROID HORMONE (1-34), RAT
Synonyms:
  • SER-VAL-SER-GLU-ILE-GLN-LEU-MET-HIS-ASN-LEU-GLY-LYS-HIS-LEU-ASN-SER-MET-GLU-ARG-VAL-GLU-TRP-LEU-ARG-LYS-LYS-LEU-GLN-ASP-VAL-HIS-ASN-PHE-VAL-ALA-LEU-GLY: SVSEIQLMHNLGKHLNSMERVEWLRKKLQDVHNFVALG
  • pTH (1-34) (rat)|PARATHYROID HORMONE (1-34),RAT
  • PTH (1-34) (RAT)
  • PARATHYROID HORMONE RAT: FRAGMENT 1-34
  • PARATHYROID HORMONE (1-34), RAT
  • RPTH 1-34
  • H-ALA-VAL-SER-GLU-ILE-GLN-LEU-MET-HIS-ASN-LEU-GLY-LYS-HIS-LEU-ALA-SER-VAL-GLU-ARG-MET-GLN-TRP-LEU-ARG-LYS-LYS-LEU-GLN-ASP-VAL-HIS-ASN-PHE-OH
  • AVSEIQLMHNLGKHLASVERMQWLRKKLQDVHNF
CAS:
98614-76-7
MF:
C180H291N55O48S2
MW:
4057.70624
Product Categories:
  • peptide
  • Parathyroid Hormone (PTH)Peptides and Proteins
  • Parathyroid Hormone Fragments
  • Hormones
  • Other Protein/Peptide Hormones
  • Peptides for Cell Biology
Mol File:
98614-76-7.mol
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PARATHYROID HORMONE (1-34), RAT Chemical Properties

storage temp. 
−20°C
solubility 
Soluble in DMSO
form 
powder
color 
Off-white to light yellow
Water Solubility 
Soluble in water or 0.1% acetic acid.
Sequence
Ala-Val-Ser-Glu-Ile-Gln-Leu-Met-His-Asn-Leu-Gly-Lys-His-Leu-Ala-Ser-Val-Glu-Arg-Met-Gln-Trp-Leu-Arg-Lys-Lys-Leu-Gln-Asp-Val-His-Asn-Phe
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Safety Information

WGK Germany 
3

MSDS

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PARATHYROID HORMONE (1-34), RAT Usage And Synthesis

Uses

Parathyroid Hormone Fragment 1-34 rat has been used to study the in vivo effect of parathyroid hormone (PTH) on the intestinal HCO3-secretion in rats. It has also been injected into rats to increase PTH levels and study its effect on the high-phosphate diet-induced elevation of blood pressure.

Biochem/physiol Actions

Parathyroid Hormone Fragment 1-34 is a parathyroid hormone (PTH) analog. It is implicated in the stimulation of intracellular cAMP accumulation and it induces osteocalcin (OC) promoter activity.

in vivo

Parathyroid hormone (1-34) (rat) (s.c; 40 mg/kg; per day; for 4 weeks) promotes the formation of bone[1].

Animal Model:ovariectomized (Ovx) rats[1]
Dosage:40 mg/kg
Administration:s.c, per day, for 4 weeks
Result:Preserved Cn-BV/TV and trabecular connectivity, and combined estrogen and PTH caused a 40% increment in Cn-BV/TV while maintaining comparable trabecular connectivity with that seen in the Shamoperated animals.
Prevented further loss of connectivity and Cn-BV/TV, and combined estrogen and PTH resulted in as much as a 300% improvement in one of the parameters of trabecular connectivity, node to node strut length, and a 106% increase in Cn-BV/TV, with respect to the bone status at the initiation of treatment.

storage

Store at -20°C

PARATHYROID HORMONE (1-34), RATSupplier

GL Biochem (Shanghai) Ltd
Tel
21-61263452 13641803416
Email
ymbetter@glbiochem.com
Shanghai Hanhong Scientific Co.,Ltd.
Tel
021-54306202 13764082696
Email
info@hanhongsci.com
Chemsky（shanghai）International Co.,Ltd.
Tel
021-50135380
Email
shchemsky@sina.com
Cellmano Biotech Limited
Tel
0551-65326643 18156095617
Email
info@cellmano.com
Sigma-Aldrich
Tel
021-61415566 800-8193336
Email
orderCN@merckgroup.com
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