DIHYDROLIPOIC ACID
DIHYDROLIPOIC ACID Basic information
- Product Name:
- DIHYDROLIPOIC ACID
- Synonyms:
-
- DHLA
- (+/-)-DIHYDROLIPOIC ACID
- DIHYDROLIPOIC ACID
- DL-ALPHA-LIPOIC ACID REDUCED FORM
- DL-ALPHA-LIPOIC ACID, DIHYDRO-
- DL-6,8-THIOCTIC ACID, REDUCED
- DL-6,8-THIOCTIC ACID REDUCED FORM
- DL-1,2-DITHIOLANE-3-PENTANOIC ACID REDUCED FORM
- CAS:
- 462-20-4
- MF:
- C8H16O2S2
- MW:
- 208.34
- EINECS:
- 610-288-5
- Mol File:
- 462-20-4.mol
DIHYDROLIPOIC ACID Chemical Properties
- Melting point:
- 62 °C
- Boiling point:
- 161.5 °C(Press: 0.7 Torr)
- Density
- 1.132 g/cm3
- vapor pressure
- 0Pa at 25℃
- refractive index
- 1.5220-1.5260
- storage temp.
- +2C to +8C
- solubility
- Chloroform (Slightly), Methanol (Slightly)
- form
- liquid
- pka
- 4.74±0.10(Predicted)
- color
- light yellow
- LogP
- 1.9 at 20℃
- Surface tension
- 53.6mN/m at 1.02g/L and 21℃
MSDS
- Language:English Provider:SigmaAldrich
DIHYDROLIPOIC ACID Usage And Synthesis
Uses
γ-Lipoic Acid, is a metabolite of α-Lipoic Acid (L468730), which is a over-the-counter nutritional supplements, that has been used as antioxidant. It is also fat-metabolism stimulator, and thus used a "weight loss" and "energy" supplement.
Definition
ChEBI: A thio-fatty acid that is reduced form of lipoic acid. A potent antioxidant shown to directly destroy superoxide, hydroperoxy and hydroxyl radicals; also has neuroprotective and anti-tumour effects.
Biological Activity
Cell permeable: no', 'Primary Target
Scavenges hypochlorous acid, peroxyl, superoxide, hydroxyl, and nitric oxide radicals', 'Product does not compete with ATP.', 'Reversible: no
in vivo
Dihydrolipoic Acid (DHLA) treatment exerts preventive effects in LPS-induced sickness behavior rats. Dihydrolipoic Acid increases the expression of ERK, Nrf2, and HO-1 but decreases the ROS generation levels and reduces the expression of NLRP3, caspase-1, and IL-1β in LPS-induced sickness behavior rats. Dihydrolipoic Acid is a reduced form of α-lipoic acid (LA) that can decrease oxidative stress and act as a strong antioxidant[2]. Dihydrolipoic Acid treatment reverses the LPS-induced sickness behavior[2].
| Animal Model: | Adult male Sprague-Dawley (SD) rats (weight, 200-220?g)[2] |
| Dosage: | 15?mg/kg, 30?mg/kg, 60?mg/kg |
| Administration: | Injected intraperitoneally daily |
| Result: | Treatment with 30?mg/kg and 60?mg/kg improved the body weight gain as compared to the LPS group. |
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DIHYDROLIPOIC ACID(462-20-4)Related Product Information
- α-Lipoic Acid
- 1,2-Dithiolane-3-pentanoic acid 1-oxide
- rac α-Lipoic Acid-d5
- Sodium (R)-alpha-lipoate
- Octanoic acid
- Lipoic acid
- R-(+)-Dihydrolipoic acid,R-(+)-Dihydrolipoic acid
- R-alpha-Lipoic acid tromethamine salt
- DIHYDROLIPOIC ACID
- OCTOTIAMINE
- (+/-)-Dihydrolipoic acid,(+/-)-Dihydrolipoic acid
- 5-[(3S)-Dithiolan-3-yl]pentanoic acid
- Sodium thioctate
- D,L-ALPHA-LIPOIC ACID-NHS
- S-(-)-Dihydrolipoic Acid,S-(-)-Dihydrolipoic Acid
- R-DHLA(R-DIHYDROLIPOIC ACID ),R-DHLA(R-DIHYDROLIPOIC ACID )
- dihydrolipoic acid methyl ester,dihydrolipoic acid methyl ester
- 1,2-DITHIOLANE-3-PENTANOIC ACID, [2-3H]