Halobetasol propionate Chemical Properties

Melting point:

213-215°C

Boiling point:

570.7±50.0 °C(Predicted)

Density 

1.31±0.1 g/cm3(Predicted)

storage temp. 

Refrigerator

solubility 

Dioxane (Sparingly), DMSO (Slightly), Methanol (Slightly)

form 

Solid

pka

12.55±0.70(Predicted)

color 

White to Off-White

InChIKey

BDSYKGHYMJNPAB-QNGYMBKVNA-N

SMILES

O([C@@]1([C@H](C[C@@]2([H])[C@]3([H])C[C@H](F)C4=CC(=O)C=C[C@]4(C)[C@@]3(F)[C@@H](O)C[C@]12C)C)C(=O)CCl)C(=O)CC |&1:1,2,4,6,9,17,19,21,24,r|

CAS DataBase Reference

66852-54-8(CAS DataBase Reference)

Safety Information

HS Code 

2937220000

MSDS

• Language:English Provider:Ulobetasol propionate

Halobetasol propionate Usage And Synthesis

Description

Halobetasol propionate is a new ultra-potent topical corticosteroid exhibiting both antiinflammatory and antihyperplasia properties. The compound is recommended for the treatment of moderate to severe corticosteroid-responsive dermatoses and appears to be particularly effective in patients with plaque psoriasis.  It inhibits dermatitis induced by ultraviolet light in guinea pigs (ED50 = 1.45 μg/animal) and by oxazolone in mice (ED50 = 0.8 μg/animal). Halobetasol propionate also has anti-inflammatory effects on croton oil-induced ear edema in rats (ED50s = 10 μg/ml and 0.5 μg/ear) and mice (ED50s = 1.2 and <0.32 μg/ear after 6 and 24 hours of treatment, respectively). Topical formulations containing halobetasol propionate have been used for inflammatory and pruritic dermatitis.

Chemical Properties

White Solid

Originator

Ciba-Geigy (Switzerland)

Uses

Halobetasol propionate is a corticosteroid (cortisone-like medicine or steroid). As an anti-inflammatory drug, halobetasol topical is used to help relieve redness, itching, swelling, or other discomfort caused by certain skin conditions. It is also used to treat plaque psoriasis.This medicine is available only with doctor's prescription.

Definition

ChEBI: Ulobetasol propionate is a corticosteroid hormone.

brand name

Ultravate (Westwood-Squibb).

Halobetasol propionate(66852-54-8)Related Product Information

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