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Halobetasol propionate

Basic information Safety Supplier Related

Halobetasol propionate Basic information

Product Name:
Halobetasol propionate
Synonyms:
  • ulobetasol propionate
  • HALOBETASOL PROPIONATE
  • BMY-30056
  • CGP-14458
  • Uiobetasol Propionate
  • Ultravate
  • 21-chloro-6alpha,9-difluoro-11beta,17-dihydroxy-16beta-methylpregna-1,4-diene-3,20-dione 17-propionate
  • 6 alpha-fluoroclobetasol 17-propionate
CAS:
66852-54-8
MF:
C25H31ClF2O5
MW:
484.96
EINECS:
686-247-0
Product Categories:
  • Inhibitors
  • Steroids
Mol File:
66852-54-8.mol
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Halobetasol propionate Chemical Properties

Melting point:
213-215°C
Boiling point:
570.7±50.0 °C(Predicted)
Density 
1.31±0.1 g/cm3(Predicted)
storage temp. 
Refrigerator
solubility 
Dioxane (Sparingly), DMSO (Slightly), Methanol (Slightly)
form 
Solid
pka
12.55±0.70(Predicted)
color 
White to Off-White
InChIKey
BDSYKGHYMJNPAB-QNGYMBKVNA-N
SMILES
O([C@@]1([C@H](C[C@@]2([H])[C@]3([H])C[C@H](F)C4=CC(=O)C=C[C@]4(C)[C@@]3(F)[C@@H](O)C[C@]12C)C)C(=O)CCl)C(=O)CC |&1:1,2,4,6,9,17,19,21,24,r|
CAS DataBase Reference
66852-54-8(CAS DataBase Reference)
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Safety Information

HS Code 
2937220000

MSDS

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Halobetasol propionate Usage And Synthesis

Description

Halobetasol propionate is a new ultra-potent topical corticosteroid exhibiting both antiinflammatory and antihyperplasia properties. The compound is recommended for the treatment of moderate to severe corticosteroid-responsive dermatoses and appears to be particularly effective in patients with plaque psoriasis.  It inhibits dermatitis induced by ultraviolet light in guinea pigs (ED50 = 1.45 μg/animal) and by oxazolone in mice (ED50 = 0.8 μg/animal). Halobetasol propionate also has anti-inflammatory effects on croton oil-induced ear edema in rats (ED50s = 10 μg/ml and 0.5 μg/ear) and mice (ED50s = 1.2 and <0.32 μg/ear after 6 and 24 hours of treatment, respectively). Topical formulations containing halobetasol propionate have been used for inflammatory and pruritic dermatitis.

Chemical Properties

White Solid

Originator

Ciba-Geigy (Switzerland)

Uses

Halobetasol propionate is a corticosteroid (cortisone-like medicine or steroid). As an anti-inflammatory drug, halobetasol topical is used to help relieve redness, itching, swelling, or other discomfort caused by certain skin conditions. It is also used to treat plaque psoriasis.This medicine is available only with doctor's prescription.

Definition

ChEBI: Ulobetasol propionate is a corticosteroid hormone.

brand name

Ultravate (Westwood-Squibb).

Halobetasol propionate Preparation Products And Raw materials

Raw materials

Halobetasol propionateSupplier

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