2,2-Dimethyl-1,3-dioxolane-4-methanol Chemical Properties

Melting point:

-27℃

Boiling point:

189-191 °C

Density 

1.066 g/mL at 20 °C(lit.)

vapor pressure 

34Pa at 20℃

refractive index 

n20/D 1.434

Flash point:

176 °F

storage temp. 

Sealed in dry,2-8°C

solubility 

172g/l soluble

form 

Liquid

pka

14.20±0.10(Predicted)

color 

Clear colorless

PH

4.0-7.5 (H2O)

Water Solubility 

miscible

Merck 

14,5213

BRN 

104465

InChIKey

RNVYQYLELCKWAN-UHFFFAOYSA-N

LogP

0.3 at 20℃

CAS DataBase Reference

100-79-8(CAS DataBase Reference)

NIST Chemistry Reference

1,3-Dioxolane-4-methanol, 2,2-dimethyl-(100-79-8)

EPA Substance Registry System

1,3-Dioxolane-4-methanol, 2,2-dimethyl- (100-79-8)

Safety Information

Hazard Codes 

Xi

Risk Statements 

36/37/38

Safety Statements 

23-24/25-36-26

WGK Germany 

2

RTECS 

JI0400000

F 

10

TSCA 

Yes

HS Code 

29329970

Toxicity

LD50 in rats (g/kg): 7 orally; 3 i.p. (Perez)

MSDS

• Language:English Provider:1,2-Isopropylidene-rac-glycerol
• Language:English Provider:SigmaAldrich
• Language:English Provider:ACROS
• Language:English Provider:ALFA

2,2-Dimethyl-1,3-dioxolane-4-methanol Usage And Synthesis

Chemical Properties

clear colourless liquid

Uses

Solketal is useful for synthesis of mono-, di- and triglycerides. It is used as the starting reagent for synthesis of tulipaline derivatives. It acts as a fuel additive in gasoline. It is an inhibitor of Methyl ethyl ketone .

Uses

DL-1,2-Isopropylideneglycerol was used as the starting reagent for synthesis of tulipaline derivatives.

Uses

A MEK inhibitor

Synthesis Reference(s)

Tetrahedron, 52, p. 9387, 1996 DOI: 10.1016/0040-4020(96)00501-7
The Journal of Organic Chemistry, 53, p. 2859, 1988 DOI: 10.1021/jo00247a043

General Description

DL-1,2-Isopropylideneglycerol undergoes effective isopropylidenation and deprotection reaction catalyzed by phosphotungstic acid.

Safety Profile

A poison by intravenous route. An eye irritant. Mutation data reported. A very dangerous fire hazard when exposed to heat or flame; can react vigorously with oxidizing materials. To fight fire, use alcohol foam, CO2, dry chemical. When heated to decomposition it emits acrid smoke and fumes.

2,2-Dimethyl-1,3-dioxolane-4-methanol(100-79-8)Related Product Information

• Dimethyl carbonate
• Dimethyl disulfide
• Lithium diisopropylamide
• Dimethyl fumarate
• N,N-Diisopropylethylamine
• Methanol
• 3-Methyl-2-butanone
• 1,3-Dioxan-5-ol
• Dimethyl ether
• Tris(hydroxymethyl)nitromethane
• Chloromethyl isopropyl carbonate
• ISOPROPYLHYDRAZINE HYDROCHLORIDE
• Dimethyl sulfoxide
• Allyl glycidyl ether
• Triisopropylsilane
• Dacthal
• ETHANE
• Glycerol