Boc-Val-Cit-PABA
Boc-Val-Cit-PABA Basic information
- Product Name:
- Boc-Val-Cit-PABA
- Synonyms:
-
- Boc-Val-Cit-PABA
- N-[(1,1-Dimethylethoxy)carbonyl]-L-valyl-N5-(aminocarbonyl)-N-[4-(hydroxymethyl)phenyl]-L-ornithinamide
- Boc-Val-Cit-PAB-OH
- (S)-2-[(S)-2-(Boc-amino)-3-methylbutanamido]-N-[4-(hydroxymethyl)phenyl]-5-ureidopentanamide
- L-Ornithinamide, N-[(1,1-dimethylethoxy)carbonyl]-L-valyl-N5-(aminocarbonyl)-N-[4-(hydroxymethyl)phenyl]-
- Boc-Gly-Gly-Phe-Gly
- tert-butyl ((S)-1-(((S)-1-((4-(hydroxymethyl)phenyl)amino)-1-oxo-5-ureidopentan-2-yl)amino)-3-methyl-1-oxobutan-2-yl)carbamate
- Pentanoicacid,2,6-dioxo-,methylester
- CAS:
- 870487-09-5
- MF:
- C23H37N5O6
- MW:
- 479.57
- Product Categories:
-
- Linker
- ADC LINKER
- ADCs
- Mol File:
- 870487-09-5.mol
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Boc-Val-Cit-PABA Chemical Properties
- Boiling point:
- 771.3±60.0 °C(Predicted)
- Density
- 1.209±0.06 g/cm3(Predicted)
- storage temp.
- 2-8°C
- solubility
- DMSO : 100 mg/mL (208.52 mM; Need ultrasonic)
- pka
- 11.25±0.46(Predicted)
- form
- Solid
- color
- White to off-white
- InChIKey
- NTAKMIJAGHASRI-ROUUACIJSA-N
- SMILES
- C(N)(=O)[C@H](CCCNC(N)=O)N(C(=O)[C@H](C(C)C)NC(OC(C)(C)C)=O)C1=CC=C(CO)C=C1
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Boc-Val-Cit-PABA Usage And Synthesis
Description
Boc-Val-Cit-PAB is a cleavable ADC linker. The Val-Cit peptide will specifically be cleaved by Cathepsin B. Boc group can be removed under acidic condition.
Uses
Boc-Val-Cit-PAB is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[1].
IC 50
Protease Cleavable Linker; Cleavable Linker
References
[1] Beck A, et al. Strategies and challenges for the next generation of antibody-drug conjugates. Nat Rev Drug Discov. 2017 May;16(5):315-337. DOI:10.1038/nrd.2016.268
Boc-Val-Cit-PABASupplier
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