Acid-PEG3-t-butyl ester Chemical Properties

Boiling point:

423.2±35.0 °C(Predicted)

Density 

1.106±0.06 g/cm3(Predicted)

storage temp. 

Storage temp. 2-8°C

solubility 

Soluble in Water, DMSO, DCM, DMF

pka

4.28±0.10(Predicted)

form 

Liquid

color 

Colorless to light yellow

InChI

InChI=1S/C14H26O7/c1-14(2,3)21-13(17)5-7-19-9-11-20-10-8-18-6-4-12(15)16/h4-11H2,1-3H3,(H,15,16)

InChIKey

VDWZJPCGUNJFEE-UHFFFAOYSA-N

SMILES

C(O)(=O)CCOCCOCCOCCC(=O)OC(C)(C)C

Safety Information

HS Code 

9999999999

Acid-PEG3-t-butyl ester Usage And Synthesis

Description

Acid-PEG3-t-butyl ester is a PEG linker containing a t-butyl protected carboxyl group with a terminal carboxylic acid. The terminal carboxylic acid can react with primary amine groups in the presence of activators (e.g. EDC, or HATU) to form a stable amide bond. The hydrophilic PEG spacer increases solubility in aqueous media. The t-butyl protected carboxyl group can be deprotected under acidic conditions.

Uses

Acid-PEG3-C2-Boc is a PEG- and Alkyl/ether-based PROTAC linker can be used in the synthesis of PROTACs for the degradation of EGFR and inhibition of mTOR[1][2].

IC 50

PEGs; Alkyl/ether

References

[1] Nathanael Gray, et al. Bifunctional molecules for degradation of egfr and methods of use. WO2017185036A1.
[2] Christopher Semko, et al. Rapamycin analogs as mtor inhibitors. WO 2018204416 A1.

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