Amino-PEG10-t-butyl ester Chemical Properties

Boiling point:

606.9±50.0 °C(Predicted)

Density 

1.074±0.06 g/cm3(Predicted)

storage temp. 

2-8°C, protect from light

form 

Liquid

pka

8.74±0.10(Predicted)

color 

Colorless to light yellow

Amino-PEG10-t-butyl ester Usage And Synthesis

Description

Amino-PEG10-t-butyl ester is a water soluble PEG reagent containing an amino group with a t-butyl protected carboxyl group. The hydrophilic PEG spacer increases solubility in aqueous media. The amino group is reactive with carboxylic acids, activated NHS esters, carbonyls (ketone, aldehyde) etc. The t-butyl protected carboxyl group can be deprotected under acidic conditions.

Uses

Amino-PEG10-Boc is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

IC 50

PEGs; Alkyl/ether

References

[1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 DOI:10.1016/j.ebiom.2018.09.005

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