Bis-PEG4-PFP ester
Bis-PEG4-PFP ester Basic information
- Product Name:
- Bis-PEG4-PFP ester
- Synonyms:
-
- PEG4 BIS-PFP ESTER
- Bis-PEG4-PFP ester
- PFP-PEG4-PFP
- 4,7,10,13-Tetraoxahexadecanedioic acid, 1,16-bis(2,3,4,5,6-pentafluorophenyl) ester
- Di(Perfluorophenyl) 4,7,10,13-Tetraoxahexadecanedioate
- Bis(perfluorophenyl) 4,7,10,13-tetraoxahexadecane-1,16-dioate
- bis(perfluorophenyl) 4,7,10,13-tetraoxahexadecanedioate
- bis(2,3,4,5,6-pentafluorophenyl) 4,7,10,13-tetraoxahexadecanedioate
- CAS:
- 1314378-12-5
- MF:
- C24H20F10O8
- MW:
- 626.39
- Mol File:
- 1314378-12-5.mol
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Bis-PEG4-PFP ester Chemical Properties
- Boiling point:
- 570.5±50.0 °C(Predicted)
- Density
- 1.473±0.06 g/cm3(Predicted)
- storage temp.
- Storage temp. 2-8°C
- solubility
- Soluble in DCM
- form
- Liquid
- color
- Colorless to light yellow
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Bis-PEG4-PFP ester Usage And Synthesis
Description
Bis-PEG4-PFP ester is a PEG linker with two terminal PFP ester moieties. PFP esters are activated esters that react with primary amines to form amide bonds. They have been found to be more stable than other amine reactive groups because they are less likely to undergo hydrolysis. The hydrophilic PEG linker increases the water solubility of the compound in aqueous media.
Uses
Bis-PEG4-PFP ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
IC 50
PEGs; Alkyl/ether
References
[1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562. DOI:10.1016/j.ebiom.2018.09.005
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