Dde Biotin-PEG4-Alkyne Chemical Properties

Boiling point:

880.0±65.0 °C(Predicted)

Density 

1.173±0.06 g/cm3(Predicted)

storage temp. 

Storage temp. 2-8°C

form 

Solid

pka

13.90±0.40(Predicted)

color 

Brown to reddish brown

Dde Biotin-PEG4-Alkyne Usage And Synthesis

Description

Dde Biotin-PEG4-alkyne is useful for introducing a biotin moiety to azide-containing molecules using Cu(I)-catalyzed Click Chemistry. The hydrophilic spacer arm provides better solubility to the labeled molecules in aqueous media. Dde protecting group allows efficient release of captured biotinylated molecules from streptavidin under mild conditions with hydrazine.

Uses

Dde Biotin-PEG4-alkyne is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. Dde Biotin-PEG4-alkyne is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

IC 50

PEGs

References

[1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 DOI:10.1016/j.ebiom.2018.09.005

Dde Biotin-PEG4-Alkyne(1802908-00-4)Related Product Information

• Methyltetrazine-PEG4-Acid
• Alkyne NHS ester (hexynoic acid NHS ester)
• Propargyl-PEG1-SS-alcohol
• Propargyl-PEG1-SS-PEG1-PFP ester
• Biotin-PEG4-Alkyne
• DSPE-PEG5-propargyl
• Methyltetrazine-PEG4-Azide
• Desthiobiotin-PEG4-Alkyne
• Tetrazine-PEG4-maleimide
• Methyltetrazine-PEG4-Amine
• Methyltetrazine-PEG5-Alkyne
• Dde Biotin-PEG4-Azide
• Bis-sulfone-PEG3-Azide
• Methyltetrazine-PEG4-NHS Ester