Propargyl-PEG3-amine CAS#: 932741-18-9

Propargyl-PEG3-amine Basic information

Product Name:

Propargyl-PEG3-amine

Synonyms:

Azido-PEG3-propargyl
Propargyl-PEG3-amine
Propargyl-PEG3-azide
HC≡C-CH2-PEG3-NH2
Propyne-PEG3-amine
Alkyne-PEG3-NH2
PROPARGYL-PEG3-NH2
3-(2-(2-(2-azidoethoxy)ethoxy)ethoxy)prop-1-yne

CAS:

932741-18-9

MF:

C9H15N3O3

MW:

213.24

Product Categories:

peg

Mol File:

932741-18-9.mol

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Propargyl-PEG3-amine Usage And Synthesis

Biological Activity

Propargyl-PEG3-azide is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].

References

[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562

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