Propargyl-PEG3-amine Usage And Synthesis

Uses

Propargyl-PEG3-azide is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. Propargyl-PEG3-azide is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.

Biological Activity

Propargyl-PEG3-azide is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].

IC 50

PEGs

References

[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562

Propargyl-PEG3-amine(932741-18-9)Related Product Information

• Propargyl-PEG3-NHS ester
• Propargyl-PEG3-t-butyl ester
• 20-Azido-3,6,9,12,15,18-hexaoxaeicosan-1-amine
• HO-PEG8-CH2CH2COOH
• Maleimide-PEG2-NHS Ester
• PEG5-acid
• alpha, oMega-Dipropionic acid hexaethylene glycol
• Bis-PEG4-acid
• Bromoacetamido-PEG4-azido
• Amino-PEG12-alcohol
• Azido-PEG4-NHS Ester
• Propargyl-PEG7-alcohol
• O-(2-AMinoethyl)-O'-(2-azidoethyl)triethylene Glycol
• Propargyl-PEG8-amine
• Propargyl-PEG13-alcohol
• Propargyl-PEG10-amine
• H2N-PEG2-Propyne
• Cy7