THP-PEG6 Chemical Properties

Boiling point:

432.5±45.0 °C(Predicted)

Density 

1.10±0.1 g/cm3(Predicted)

pka

14.36±0.10(Predicted)

THP-PEG6 Usage And Synthesis

Description

THP-PEG7 is a PEG linker containing a THP protecting group and a hydroxyl group. THP is acid labile and is commonly used for the protection of alcohol groups. The terminal hydroxyl group can be further reacted to derivatize the compound. The hydrophilic PEG linker increases the water solubility of compounds in aqueous media.

Uses

THP-PEG5-OH is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

IC 50

PEGs

References

[1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562. DOI:10.1016/j.ebiom.2018.09.005

THP-PEG6(146395-14-4)Related Product Information

• THP-PEG6-alcohol
• THP-PEG3-alcohol
• THP-PEG12-alcohol
• TETRAHYDROPYRANYLDIETHYLENEGLYCOL
• THP-PEG8-alcohol
• THP-PEG5
• THP-PEG4
• THP-PEG7-OH