1,2,3,4-TETRAHYDRO-6-QUINOLINECARBOXYLIC ACID Chemical Properties

Melting point:

168 °C

Boiling point:

382.6±31.0 °C(Predicted)

Density 

1.223±0.06 g/cm3(Predicted)

storage temp. 

Keep in dark place,Inert atmosphere,Room temperature

pka

4.96±0.20(Predicted)

Appearance

Off-white to yellow Solid

Safety Information

Hazard Codes 

Xi,T

Risk Statements 

25

Safety Statements 

45

Hazard Note 

Irritant

HS Code 

2933499090

1,2,3,4-TETRAHYDRO-6-QUINOLINECARBOXYLIC ACID Usage And Synthesis

Synthesis Reference(s)

The Journal of Organic Chemistry, 39, p. 2044, 1974 DOI: 10.1021/jo00928a014

Synthesis

GENERAL STEPS: 1-Acetyl-1,2,3,4-tetrahydroquinoline-6-carbonitrile (50 mmol) was dissolved in 8 M hydrochloric acid (150 mL) and the reaction was carried out at reflux for 18 hours. Upon completion of the reaction, the mixture was cooled and the pH was adjusted with sodium hydroxide solution to about 3. The precipitated 1,2,3,4-tetrahydroquinoline-6-carboxylic acid was separated by filtration, washed with water and dried. Yield: 61%.1H NMR (D6-DMSO) δ: 1.79 (m, 2H), 2.68 (m, 2H), 3.23 (m, 2H), 5.45 (br, 1H), 6.48 (d, 1H), 7.45-7.50 (m, 2H).

References

[1] Patent: WO2005/39572, 2005, A1. Location in patent: Page/Page column 31-32

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