ChemicalBook > Product Catalog > Chemical Reagents > Organic reagents > Esters > Ethyl compound > Ethyl 2-chloronicotinate
Ethyl 2-chloronicotinate
Ethyl 2-chloronicotinate Basic information
- Product Name:
- Ethyl 2-chloronicotinate
- Synonyms:
-
- ETHYL 2-CHLORONICOTINATE
- ethyl 2-chloropyridine-3-carboxylate
- 2-CHLORONICOTINIC ACID ETHYL ESTER
- 2-Chloro-3-pyridinecarboxylic acid ethyl ester
- 2-Chloropyridine-3-carboxylic acid ethyl ester
- Ethyl 2-chloronicoti
- Ethyl 2-Chloro-3-pyridinecarboxylate
- 2-Chloronicotinic Acid Ethyl Ester Ethyl 2-Chloro-3-pyridinecarboxylate 2-Chloro-3-pyridinecarboxylic Acid Ethyl Ester
- CAS:
- 1452-94-4
- MF:
- C8H8ClNO2
- MW:
- 185.61
- Product Categories:
-
- pyridine series
- Pyridines
- Pharmaceutical Intermediates
- Pyridine
- Fluorobenzene
- Mol File:
- 1452-94-4.mol
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Ethyl 2-chloronicotinate Chemical Properties
- Melting point:
- 68 C
- Boiling point:
- 78°C (0.1 mmHg)
- Density
- 1.2445 g/cm3(Temp: 25 °C)
- refractive index
- 1.5210-1.5250
- storage temp.
- Keep in dark place,Sealed in dry,Room Temperature
- pka
- -1.32±0.10(Predicted)
- form
- Liquid
- color
- Colorless to Light yellow to Light orange
- InChI
- InChI=1S/C8H8ClNO2/c1-2-12-8(11)6-4-3-5-10-7(6)9/h3-5H,2H2,1H3
- InChIKey
- PMIMPBYTPPRBGD-UHFFFAOYSA-N
- SMILES
- C1(Cl)=NC=CC=C1C(OCC)=O
- CAS DataBase Reference
- 1452-94-4(CAS DataBase Reference)
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Safety Information
- Hazard Codes
- Xi
- Risk Statements
- 36/37/38
- Safety Statements
- 26-37/39-60-37
- HazardClass
- IRRITANT
- HS Code
- 29333990
MSDS
- Language:English Provider:ALFA
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Ethyl 2-chloronicotinate Usage And Synthesis
Chemical Properties
Light yellow liquid
Uses
Ethyl 2-chloronicotinate,is used as a pharmaceutical intermediate.
Synthesis Reference(s)
Tetrahedron, 51, p. 13177, 1995 DOI: 10.1016/0040-4020(95)00788-A
Synthesis
2-Chloropyridine-3-carboxylic acid (7.9 g) and thionyl chloride (45 ml) were heated for 3 hours in benzene (65 ml) under reflux. The reaction mixture was concentrated to leave an oil, which was added dropwise to ethanol (40 ml). The mixture was heated for a further one hour under reflux. The solvent was distilled, and the residue was dissolved in toluene. The solution was dried over anhydrous magnesium sulfate. The solvent was distilled to leave Ethyl 2-chloronicotinate (8.4 g, 90%) as a pale yellow oil.
Ethyl 2-chloronicotinateSupplier
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Ethyl 2-chloronicotinate(1452-94-4)Related Product Information
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- ethyl 4-chloronicotinate
- Ethyl 4,6-dichloronicotinate
- ETHYL 6-CHLORONICOTINATE,6-Chloronicotinic acid ethyl ester (Ethyl-6-Chloronicotinate),Ethyl6-chloronicotinate,97%,ETHYL 6-CHLORONICOTINATE[FOR TAZAROTENE]
- Ethyl nicotinate
- 2-Chloronicotinic acid
- 2-CHLORO-5-ETHYLPYRIDINE-3-CARBOXYLIC ACID ETHYL ESTER
- 2,4-Dichloro-quinoline-3-carboxylic acid ethyl ester
- 2-Chloro-3-quinolinecarboxylic acid ethyl ester
- Ethyl 5-chloronicotinate
- ETHYL 4-CHLORONICOTINATE HCL
- 2,4,5,6-TETRACHLORO-NICOTINIC ACID ETHYL ESTER
- ETHYL 2-CHLORO-6-METHYL-4-[(4-METHYLPHENYL)THIO]NICOTINATE
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- AURORA KA-5327