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Ethyl 2-chloronicotinate

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Ethyl 2-chloronicotinate Basic information

Product Name:
Ethyl 2-chloronicotinate
Synonyms:
  • ETHYL 2-CHLORONICOTINATE
  • ethyl 2-chloropyridine-3-carboxylate
  • 2-CHLORONICOTINIC ACID ETHYL ESTER
  • 2-Chloro-3-pyridinecarboxylic acid ethyl ester
  • 2-Chloropyridine-3-carboxylic acid ethyl ester
  • Ethyl 2-chloronicoti
  • Ethyl 2-Chloro-3-pyridinecarboxylate
  • 2-Chloronicotinic Acid Ethyl Ester Ethyl 2-Chloro-3-pyridinecarboxylate 2-Chloro-3-pyridinecarboxylic Acid Ethyl Ester
CAS:
1452-94-4
MF:
C8H8ClNO2
MW:
185.61
Product Categories:
  • pyridine series
  • Pyridines
  • Pharmaceutical Intermediates
  • Pyridine
  • Fluorobenzene
Mol File:
1452-94-4.mol
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Ethyl 2-chloronicotinate Chemical Properties

Melting point:
68 C
Boiling point:
78°C (0.1 mmHg)
Density 
1.2445 g/cm3(Temp: 25 °C)
refractive index 
1.5210-1.5250
storage temp. 
Keep in dark place,Sealed in dry,Room Temperature
pka
-1.32±0.10(Predicted)
form 
Liquid
color 
Colorless to Light yellow to Light orange
InChI
InChI=1S/C8H8ClNO2/c1-2-12-8(11)6-4-3-5-10-7(6)9/h3-5H,2H2,1H3
InChIKey
PMIMPBYTPPRBGD-UHFFFAOYSA-N
SMILES
C1(Cl)=NC=CC=C1C(OCC)=O
CAS DataBase Reference
1452-94-4(CAS DataBase Reference)
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Safety Information

Hazard Codes 
Xi
Risk Statements 
36/37/38
Safety Statements 
26-37/39-60-37
HazardClass 
IRRITANT
HS Code 
29333990

MSDS

  • Language:English Provider:ALFA
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Ethyl 2-chloronicotinate Usage And Synthesis

Chemical Properties

Light yellow liquid

Uses

Ethyl 2-chloronicotinate,is used as a pharmaceutical intermediate.

Synthesis Reference(s)

Tetrahedron, 51, p. 13177, 1995 DOI: 10.1016/0040-4020(95)00788-A

Synthesis

2-Chloropyridine-3-carboxylic acid (7.9 g) and thionyl chloride (45 ml) were heated for 3 hours in benzene (65 ml) under reflux. The reaction mixture was concentrated to leave an oil, which was added dropwise to ethanol (40 ml). The mixture was heated for a further one hour under reflux. The solvent was distilled, and the residue was dissolved in toluene. The solution was dried over anhydrous magnesium sulfate. The solvent was distilled to leave Ethyl 2-chloronicotinate (8.4 g, 90%) as a pale yellow oil.

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