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BAFILOMYCIN B1

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BAFILOMYCIN B1 Basic information

Product Name:
BAFILOMYCIN B1
Synonyms:
  • BAFILOMYCIN B1
  • BAFILOMYCIN B1 MONOHYDRATE FROM STREPTO- MYCES SPECIES
  • BafilomycinB1fromStreptomycesgriseus
  • bafilomycin b1from streptomyces sp.
  • hygrolidin,37-decarboxy-2-demethyl-37-(((2-hydroxy-5-oxo-1-cyclopenten-1-yl)am
  • ino)carbonyl)-2-methoxy-24-methyl-
  • 37-De(carboxy)-2-demethyl-37-[[(2-hydroxy-5-oxo-1-cyclopenten-1-yl)amino]carbonyl]-2-methoxy-24-methylhygrolidin
  • 2-Butenoic acid, 4-[(2-hydroxy-5-oxo-1-cyclopenten-1-yl)amino]-4-oxo-, (2R,4R,5S,6R)-tetrahydro-2-hydroxy-2-[(1S,2R,3S)-2-hydroxy-3-[(2R,3S,4E,6E,9S,10S,11R,12E,14Z)-10-hydroxy-3,15-dimethoxy-7,9,11,13-tetramethyl-16-oxooxacyclohexadeca-4,6,12,14-tetraen-2-yl]-1-methylbutyl]-5-methyl-6-(1-methylethy...
CAS:
88899-56-3
MF:
C44H65NO13
MW:
815.99
Product Categories:
  • Antibiotic
  • MacrolidesMore...Close...
  • A - KAntibiotics
  • Antibacterial
  • Antibiotics A to
  • Antibiotics A-FAntibiotics
  • Antibiotics by Application
  • AntifungalAntibiotics
  • Antineoplastic and Immunosuppressive AntibioticsAntibiotics
  • Chemical Structure Class
  • Inhibits an EnzymeAntibiotics
  • Mechanism of Action
  • Spectrum of Activity
Mol File:
88899-56-3.mol
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BAFILOMYCIN B1 Chemical Properties

storage temp. 
−20°C
solubility 
DMSO: Soluble; Methanol: Unstable
form 
powder or crystals
color 
faint yellow to yellow
BRN 
4640118
Stability:
Hygroscopic
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Safety Information

Hazard Codes 
T+
Risk Statements 
26/27/28
Safety Statements 
36/37/39-45
RIDADR 
UN 3462 6.1/PG 1
WGK Germany 
3
RTECS 
NG8841000
10-21
HazardClass 
3
HS Code 
2941900000
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BAFILOMYCIN B1 Usage And Synthesis

Description

Bafilomycin B1 is a fungal metabolite that has been found in Streptomyces and has diverse biological activities. It inhibits the activity of rat liver lysosomal vacuolar H+-ATPase (V-ATPase) in a concentration-dependent manner. Bafilomycin B1 (10-1,000 nM) induces autophagosome accumulation in MCF-7 cells. It inhibits chloroquine-induced apoptosis in primary cerebellar granule neurons (CGNs) when used at a concentration of 1 nM. Bafilomycin B1 reduces viral genome copy numbers in the culture supernatant of Vero E6 cells infected with H1N1 influenza A.

Uses

Bafilomycin B1 is a member of a potent family of macrocyclic lactones. Bafilomycin B1 shares the same mode of action and activity as its more accessible A1 analogue. Bafilomycin B1 is broadly active against bacteria, fungi, insects, nematodes and protozoans. Bafilomycin B1 has attracted interest as a potential agent for treating osteoporosis.

BAFILOMYCIN B1Supplier

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