BAFILOMYCIN B1
BAFILOMYCIN B1 Basic information
- Product Name:
- BAFILOMYCIN B1
- Synonyms:
-
- BAFILOMYCIN B1
- BAFILOMYCIN B1 MONOHYDRATE FROM STREPTO- MYCES SPECIES
- BafilomycinB1fromStreptomycesgriseus
- bafilomycin b1from streptomyces sp.
- hygrolidin,37-decarboxy-2-demethyl-37-(((2-hydroxy-5-oxo-1-cyclopenten-1-yl)am
- ino)carbonyl)-2-methoxy-24-methyl-
- 37-De(carboxy)-2-demethyl-37-[[(2-hydroxy-5-oxo-1-cyclopenten-1-yl)amino]carbonyl]-2-methoxy-24-methylhygrolidin
- 2-Butenoic acid, 4-[(2-hydroxy-5-oxo-1-cyclopenten-1-yl)amino]-4-oxo-, (2R,4R,5S,6R)-tetrahydro-2-hydroxy-2-[(1S,2R,3S)-2-hydroxy-3-[(2R,3S,4E,6E,9S,10S,11R,12E,14Z)-10-hydroxy-3,15-dimethoxy-7,9,11,13-tetramethyl-16-oxooxacyclohexadeca-4,6,12,14-tetraen-2-yl]-1-methylbutyl]-5-methyl-6-(1-methylethy...
- CAS:
- 88899-56-3
- MF:
- C44H65NO13
- MW:
- 815.99
- Product Categories:
-
- Antibiotic
- MacrolidesMore...Close...
- A - KAntibiotics
- Antibacterial
- Antibiotics A to
- Antibiotics A-FAntibiotics
- Antibiotics by Application
- AntifungalAntibiotics
- Antineoplastic and Immunosuppressive AntibioticsAntibiotics
- Chemical Structure Class
- Inhibits an EnzymeAntibiotics
- Mechanism of Action
- Spectrum of Activity
- Mol File:
- 88899-56-3.mol
BAFILOMYCIN B1 Chemical Properties
- storage temp.
- −20°C
- solubility
- DMSO: Soluble; Methanol: Unstable
- form
- powder or crystals
- color
- faint yellow to yellow
- BRN
- 4640118
- Stability:
- Hygroscopic
Safety Information
- Hazard Codes
- T+
- Risk Statements
- 26/27/28
- Safety Statements
- 36/37/39-45
- RIDADR
- UN 3462 6.1/PG 1
- WGK Germany
- 3
- RTECS
- NG8841000
- F
- 10-21
- HazardClass
- 3
- HS Code
- 2941900000
BAFILOMYCIN B1 Usage And Synthesis
Description
Bafilomycin B1 is a fungal metabolite that has been found in Streptomyces and has diverse biological activities. It inhibits the activity of rat liver lysosomal vacuolar H+-ATPase (V-ATPase) in a concentration-dependent manner. Bafilomycin B1 (10-1,000 nM) induces autophagosome accumulation in MCF-7 cells. It inhibits chloroquine-induced apoptosis in primary cerebellar granule neurons (CGNs) when used at a concentration of 1 nM. Bafilomycin B1 reduces viral genome copy numbers in the culture supernatant of Vero E6 cells infected with H1N1 influenza A.
Uses
Bafilomycin B1 is a member of a potent family of macrocyclic lactones. Bafilomycin B1 shares the same mode of action and activity as its more accessible A1 analogue. Bafilomycin B1 is broadly active against bacteria, fungi, insects, nematodes and protozoans. Bafilomycin B1 has attracted interest as a potential agent for treating osteoporosis.
BAFILOMYCIN B1Supplier
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BAFILOMYCIN B1(88899-56-3)Related Product Information
- B-1
- Doxycycline
- BAFILOMYCIN B2
- BAFILOMYCIN A1 (DRY ICE)
- Bafilomycin A2
- Bafilomycin C2
- Bafilomycin A1 from Streptomycesgriseus, 10 ug,BAFILOMYCIN A1, 98+%,BAFILOMYCIN A1 95%,BAFILOMYCIN A1, STREPTOMYCES GRISEUS,BAFILOMYCIN A1
- Bafilomycin D2'
- Bafilomycin E
- Bafilomycin D1
- BAFILOMYCIN C1
- bafilomycin D
- BAFILOMYCIN B1 MONOHYDRATE
- BAFILOMYCIN B2 FROM STREPTOMYCES GRISEUS