N-desalkylflurazepam Chemical Properties

Melting point:

204-206°C

Boiling point:

454.0±45.0 °C(Predicted)

Density 

1.39±0.1 g/cm3(Predicted)

Flash point:

9℃

storage temp. 

Sealed in dry,Room Temperature

solubility 

Chloroform (Slightly), Methanol (Slightly)

form 

A neat solid

pka

11.55±0.70(Predicted)

InChI

InChI=1S/C15H10ClFN2O/c16-9-5-6-13-11(7-9)15(18-8-14(20)19-13)10-3-1-2-4-12(10)17/h1-7H,8H2,(H,19,20)

InChIKey

UVCOILFBWYKHHB-UHFFFAOYSA-N

SMILES

N1C2=CC=C(Cl)C=C2C(C2=CC=CC=C2F)=NCC1=O

CAS DataBase Reference

2886-65-9(CAS DataBase Reference)

NIST Chemistry Reference

Norfludiazepam(2886-65-9)

Safety Information

Hazard Codes 

F,T

Risk Statements 

11-23/24/25-39/23/24/25

Safety Statements 

22-24/25-45-36/37-16-7

RIDADR 

UN1230 - class 3 - PG 2 - Methanol, solution

WGK Germany 

2

RTECS 

DF2370100

HS Code 

2933997500

MSDS

• Language:English Provider:SigmaAldrich

N-desalkylflurazepam Usage And Synthesis

Description

Desalkylflurazepam (Item No. 18484) is an analytical reference material that is structurally categorized as a benzodiazepine. It is an active metabolite of several benzodiazepines, including flurazepam , flutoprazepam, fludiazepam, midazolam, and quazepam. Desalkylflurazepam inhibits L-type voltage-gated calcium channels (Ca_v; IC₅₀s = 55 and 37 μM for Ca_v1.2 and 1.3, respectively) by positively modulating GABA_A receptors. It can be detected in urine, serum, and meconium by LC-MS/MS. This product is intended for research and forensic applications.

Chemical Properties

Light Yellow Solid

Uses

The major human metabolite of flurazepam. This is a controlled drug precursor therefore a liscence may be required for purchase

Definition

ChEBI: Desalkylflurazepam is a benzodiazepine.

General Description

N-Desalkylflurazepam (also known as norflurazepam, 2886-65-9) is a benzodiazepine analog and an active metabolite of several other benzodiazepine drugs including flurazepam, flutoprazepam, fludiazepam, midazolam, flutazolam, quazepam, and ethyl loflazepate. It is long-acting, prone to accumulation, and binds unselectively to the various benzodiazepine receptor subtypes. It has been sold as a designer drug from 2016 onward.

Mode of action

N-Desalkylflurazepam is a benzodiazepine analog and an active metabolite of several other benzodiazepine drugs including flurazepam, flutoprazepam, fludiazepam, midazolam, flutazolam, quazepam, and ethyl loflazepate. It is long-acting, prone to accumulation, and binds unselectively to the various benzodiazepine receptor subtypes. It has been sold as a designer drug from 2016 onward.

N-desalkylflurazepam(2886-65-9)Related Product Information

• CHLOROPHENYLSILANE 97
• Hydrochlorothiazide
• tert-Butylchlorodiphenylsilane
• Epichlorohydrin
• PHENYL VALERATE
• Chlorodimethylphenylsilane
• DBU
• Triphenylmethyl Chloride
• Phenylhydrazine
• Dihydromyrcenol
• 7-Chloro-5-(2-fluorophenyl)-1,3-dihydro-3-hydroxy-2H-1,4-benzodiazepin-2-one
• FLURAZEPAM DIHYDROCHLORIDE
• Doxefazepam
• Elfazepam
• Chloroacetic acid
• Proflazepam
• Difluorochloromethane
• Fludiazepam