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N-desalkylflurazepam

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N-desalkylflurazepam Basic information

Product Name:
N-desalkylflurazepam
Synonyms:
  • NORFLUDIAZEPAM
  • Dealkylflurazepam
  • Descarbethoxyloflazepate
  • Flurazepam M (des-alkyl)
  • Flurazepam M (N-1-des-alkyl)
  • Flurazepam, des-alkyl
  • N-1-desalkyl-flurazepam
  • N-Desalkyl-2-oxoquazepam
CAS:
2886-65-9
MF:
C15H10ClFN2O
MW:
288.7
EINECS:
220-748-3
Product Categories:
  • Intermediates & Fine Chemicals
  • Pharmaceuticals
  • pharmacetical
  • (intermediate of fludiazepam,flurazepam)
  • Aromatics
  • Heterocycles
  • medical intermediate
Mol File:
2886-65-9.mol
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N-desalkylflurazepam Chemical Properties

Melting point:
204-206°C
Boiling point:
454.0±45.0 °C(Predicted)
Density 
1.39±0.1 g/cm3(Predicted)
Flash point:
9℃
storage temp. 
Sealed in dry,Room Temperature
solubility 
Chloroform (Slightly), Methanol (Slightly)
form 
A neat solid
pka
11.55±0.70(Predicted)
color 
White to off-white
InChI
InChI=1S/C15H10ClFN2O/c16-9-5-6-13-11(7-9)15(18-8-14(20)19-13)10-3-1-2-4-12(10)17/h1-7H,8H2,(H,19,20)
InChIKey
UVCOILFBWYKHHB-UHFFFAOYSA-N
SMILES
N1C2=CC=C(Cl)C=C2C(C2=CC=CC=C2F)=NCC1=O
CAS DataBase Reference
2886-65-9(CAS DataBase Reference)
NIST Chemistry Reference
Norfludiazepam(2886-65-9)
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Safety Information

Hazard Codes 
F,T
Risk Statements 
11-23/24/25-39/23/24/25
Safety Statements 
22-24/25-45-36/37-16-7
RIDADR 
UN1230 - class 3 - PG 2 - Methanol, solution
WGK Germany 
2
RTECS 
DF2370100
HS Code 
2933997500

MSDS

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N-desalkylflurazepam Usage And Synthesis

Description

Desalkylflurazepam (Item No. 18484) is an analytical reference material that is structurally categorized as a benzodiazepine. It is an active metabolite of several benzodiazepines, including flurazepam , flutoprazepam, fludiazepam, midazolam, and quazepam. Desalkylflurazepam inhibits L-type voltage-gated calcium channels (Cav; IC50s = 55 and 37 μM for Cav1.2 and 1.3, respectively) by positively modulating GABAA receptors. It can be detected in urine, serum, and meconium by LC-MS/MS. This product is intended for research and forensic applications.

Chemical Properties

Light Yellow Solid

Uses

The major human metabolite of flurazepam. This is a controlled drug precursor therefore a liscence may be required for purchase

Definition

ChEBI: Desalkylflurazepam is a benzodiazepine.

General Description

N-Desalkylflurazepam (also known as norflurazepam, 2886-65-9) is a benzodiazepine analog and an active metabolite of several other benzodiazepine drugs including flurazepam, flutoprazepam, fludiazepam, midazolam, flutazolam, quazepam, and ethyl loflazepate. It is long-acting, prone to accumulation, and binds unselectively to the various benzodiazepine receptor subtypes. It has been sold as a designer drug from 2016 onward.

Mode of action

N-Desalkylflurazepam is a benzodiazepine analog and an active metabolite of several other benzodiazepine drugs including flurazepam, flutoprazepam, fludiazepam, midazolam, flutazolam, quazepam, and ethyl loflazepate. It is long-acting, prone to accumulation, and binds unselectively to the various benzodiazepine receptor subtypes. It has been sold as a designer drug from 2016 onward.

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