1,1,1-Trifluoroethyl-PEG4-Aminooxy Chemical Properties

Boiling point:

348.3±42.0 °C(Predicted)

Density 

1.186±0.06 g/cm3(Predicted)

pka

4.21±0.70(Predicted)

1,1,1-Trifluoroethyl-PEG4-Aminooxy Usage And Synthesis

Description

1,1,1-Trifluoroethyl-PEG4-aminooxy is a fluorine containing PEG molecule. The aminooxy group can be used in bioconjugation and It reacts with an aldehyde to form an oxime bond. Aminooxy compounds are very reactive and sensitive; they cannot be stored for long term. Immediate use (within 1 week) is highly recommended.

Uses

1,1,1-Trifluoroethyl-PEG4-aminooxy is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

IC 50

PEGs

References

[1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 DOI:10.1016/j.ebiom.2018.09.005

1,1,1-Trifluoroethyl-PEG4-Aminooxy(1895922-78-7)Related Product Information

• 1,1,1-Trifluoroethyl-PEG3-Propargyl
• 1,1,1-Trifluoroethyl-PEG4-azide
• 1,1,1-Trifluoroethyl-PEG5-Alcohol
• 1,1,1-Trifluoroethyl-PEG2-azide
• 1,1,1-Trifluoroethyl-PEG4-amine
• 1,1,1-Trifluoroethyl-PEG5-Propargyl