4-amino-7-iodopyrrolo [2,1-f ] [1,2,4] triazine Chemical Properties

Density 

2.43±0.1 g/cm3(Predicted)

pka

3.04±0.30(Predicted)

form 

solid

color 

Pale yellow

InChI

InChI=1S/C6H5IN4/c7-5-2-1-4-6(8)9-3-10-11(4)5/h1-3H,(H2,8,9,10)

InChIKey

ZEBGLCLVPCOXIV-UHFFFAOYSA-N

SMILES

N12C(I)=CC=C1C(N)=NC=N2

Safety Information

HS Code 

2933998090

4-amino-7-iodopyrrolo [2,1-f ] [1,2,4] triazine Usage And Synthesis

Uses

4-amino-7-iodopyrrolo[2,1-f][1,2,4]triazine is an amine organic substance and can be used as an intermediate for APIs.

Uses

7-Iodopyrrolo[2,1-f][1,2,4]triazin-4-amine is a useful reagent in the synthesis of phosphoramidate GS-5734 prodrug for potential treatment of Ebola virus infections and in the preparation of Remdesivir as COVID-19 antiviral drug candidate.

Synthesis

The synthesis reaction of 4-amino-7-iodopyrrolo [2,1-f ] [1,2,4] triazine is as follows: 4-amino pyrrolo [2,1-f ] [1,2,4] triazine reacts with iodine or iodine chloride under mild conditions to generate most of iodinated products, isomers and diiodized products are not generated under the mild conditions, and unreacted materials react with N-iodosuccinimide to further ensure that raw materials completely react, so that the conversion rate of the raw materials is improved, and the generation of the isomer products and the diiodized products is also inhibited.

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