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Roxarsone

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Roxarsone Basic information

Product Name:
Roxarsone
Synonyms:
  • 2-NITROPHENOL-4-ARSONIC ACID
  • 4-HYDROXY-3-NITROBENZENENEARSONIC ACID
  • 4-HYDROXY-3-NITROBENZENEARSONIC ACID
  • 4-HYDROXY-3-NITROPHENYLARSONIC ACID
  • 4-Hydroxy-3-nitrobenzenearsonic acid,98%
  • Roxarsone (200 mg)
  • Roxasone
  • p-Hydroxy-M-nitrophenylarsonic Acid
CAS:
121-19-7
MF:
C6H6AsNO6
MW:
263.04
EINECS:
204-453-7
Product Categories:
  • Pharmaceutical intermediates
  • MERTHIOLATE
  • Organometallics
  • As (Arsenic) Compounds
  • Classes of Metal Compounds
  • Semimetal Compounds
Mol File:
121-19-7.mol
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Roxarsone Chemical Properties

Melting point:
≥300 °C(lit.)
Boiling point:
537.3±60.0 °C(Predicted)
Density 
2.02 g/cm3
storage temp. 
0-6°C
solubility 
insoluble in Ether
pka
3.51±0.10(Predicted)
form 
liquid
color 
Light yellow to Yellow
Water Solubility 
<0.1 g/100 mL at 23 ºC
Merck 
14,8273
BRN 
1976533
Stability:
Hygroscopic
InChIKey
XMVJITFPVVRMHC-UHFFFAOYSA-N
CAS DataBase Reference
121-19-7(CAS DataBase Reference)
EPA Substance Registry System
Roxarsone (121-19-7)
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Safety Information

Hazard Codes 
T,N
Risk Statements 
23/25-50/53
Safety Statements 
20/21-28-45-60-61
RIDADR 
UN 3465 6.1/PG 2
WGK Germany 
3
RTECS 
CY5250000
HazardClass 
6.1(b)
PackingGroup 
III
HS Code 
29319090
Hazardous Substances Data
121-19-7(Hazardous Substances Data)
Toxicity
LD50 in rats, chickens (mg/kg): 155, 110-123 orally; 66, 34 i.p. (Kerr)

MSDS

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Roxarsone Usage And Synthesis

Chemical Properties

BEIGE-BROWN FINE CRYSTALLINE POWDER

Uses

antiinfective, preservative

Uses

4-Hydroxy-3-nitrophenylarsonic Acid is used as a feed additive for chicken to aid in the prevention of coccidiosis caused by E[imeria] tenella and E. necatrix.

Uses

Formerly in manufacture of arsphenamines; as reagent for zirconium.

Definition

ChEBI: An organoarsonic acid where the organyl group is 4-hydroxy-3-nitrophenyl.

General Description

Pale yellow crystals or light tan powder.

Air & Water Reactions

Insoluble in water.

Reactivity Profile

May be sensitive to light and elevated temperatures on long-term storage. Roxarsone puffs up and deflagrates on heating. Incompatible with strong oxidizers and strong acids. Forms mono-, di-, and trisodium salts.

Hazard

Toxic by ingestion, highly toxic.

Fire Hazard

Flash point data are not available for Roxarsone ; however, Roxarsone is probably combustible.

Purification Methods

It crystallises from water and is used for the spectroscopic detection of Zn. [Beilstein 16 II 468, 16 III 1073, 16 IV 1188.]

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