Ethanol, 2-[2-[2-(triphenylmethoxy)ethoxy]ethoxy]- Chemical Properties

Boiling point:

521.8±45.0 °C(Predicted)

Density 

1.126±0.06 g/cm3(Predicted)

storage temp. 

Storage temp. 2-8°C

form 

Viscous Liquid

pka

14.36±0.10(Predicted)

color 

Colorless to light yellow

Ethanol, 2-[2-[2-(triphenylmethoxy)ethoxy]ethoxy]- Usage And Synthesis

Description

Tr-PEG4 is a PEG linker containing a trityl, alcohol protecting group and a terminal hydroxyl group. Trityl can be removed under acidic conditions. The hydroxyl group can undergo various reactions in order to further derivatize the compound. The hydrophilic PEG linkers increase the solubility of compounds in aqueous media.

Uses

Tr-PEG3-OH is a non-cleavable 3 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs).

References

[1] Chou CH, et al. Glycan-Directed Grafting-from Polymerization of Immunoglobulin G: Site-Selectively Modified IgG-Polymer Conjugates with Preserved Biological Activity. Biomacromolecules. 2018 Jul 9;19(7):3086-3095. DOI:10.1016/s0950-3528(98)90140-3

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