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Diphenhydramine citrate

Basic information Safety Supplier Related

Diphenhydramine citrate Basic information

Product Name:
Diphenhydramine citrate
Synonyms:
  • [2-(diphenylmethoxy)ethyl]dimethylammonium dihydrogen 2-hydroxypropane-1,2,3-tricarboxylate
  • Diphenhydramine Citrate (125 mg)
  • Diphenhydramine Citrate (200 mg)
  • 2-(benzhydryloxy)-N,N-diMethylethanaMine 2-hydroxypropane-1,2,3-tricarboxylate
  • Benzhydramine citrate
  • DIPHENHYDRAMINE CITRATE
  • Diphenhydramine citrate USP/EP/BP
  • 2-benzhydryloxy-N,N-dimethylethanamine,2-hydroxypropane-1,2,3-tricarboxylic acid
CAS:
88637-37-0
MF:
C23H29NO8
MW:
447.48
EINECS:
289-432-0
Mol File:
88637-37-0.mol
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Diphenhydramine citrate Chemical Properties

Melting point:
148-150°C
storage temp. 
Room Temperature
solubility 
DMSO, Methanol
form 
Solid
color 
White
Major Application
pharmaceutical
InChIKey
SPCKHVPPRJWQRZ-UHFFFAOYSA-N
SMILES
N(CCOC(c2ccccc2)c1ccccc1)(C)C.OC(CC(=O)O)(CC(=O)O)C(=O)O
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Safety Information

WGK Germany 
3
HS Code 
2922190900
Storage Class
11 - Combustible Solids
Hazard Classifications
Acute Tox. 4 Oral
Eye Irrit. 2
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Diphenhydramine citrate Usage And Synthesis

Uses

Antihistaminic.

Uses

Diphenhydramine is a H1-histamine receptor antagonist. Diphenhydramine is categorized as an antihistaminic; sedative, hypnotic.

Synthesis

Benzylhydramine hydrochloride is produced by reacting benzylhydramine hydrochloride with sodium hydroxide, and then benzylhydramine citrate is produced by reacting benzylhydramine citrate with citric acid. However, this method uses benzylamine hydrochloride as the starting material and is costly.

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