EBELACTONE A Chemical Properties

storage temp. 

2-8°C

solubility 

DMF: 25 mg/ml; DMF:PBS(pH 7.2)(1:1): 0.5 mg/ml; DMSO: 25 mg/ml; Ethanol: 20 mg/ml

form 

White crystalline powder.

biological source

Streptomyces sp.

Safety Information

WGK Germany 

3

RTECS 

RQ7730000

MSDS

• Language:English Provider:SigmaAldrich

EBELACTONE A Usage And Synthesis

Description

Ebelactone A is a β-lactone enzyme inhibitor that was first isolated from a cultured strain of soil actinomycetes. It can inhibit esterases, lipases, and N-formylmethionine aminopeptidases (IC₅₀s = 0.056, 0.003, and 0.08 μg/ml, respectively) found on cell surfaces, which has been shown to stimulate host defense in immune cells. Ebelactone A is also reported to inhibit cutinases produced by fungal pathogens, thus demonstrating a plant-protective function.

Uses

Ebelactone A is a mycolic acid β-lactone, which exhibits inhibitory activity for esterase, lipase, fMet aminopeptidase (fMet AP) and PNBase, with IC50s of 56, 3, 8 and 7.5 μM, respectively[1]. Ebelactone A inhibits cutinase, exhibits plants protective potency against Erysiphe graminis[2].

References

[1] Umezawa H, et al., Ebelactone, an inhibitor of esterase, produced by actinomycetes. J Antibiot (Tokyo). 1980 Dec;33(12):1594-6. DOI:10.7164/antibiotics.33.1594
[2] Francis S A, et al., The role of cutinase in germling development and infection byErysiphe graminisf. sp. hordei[J]. Physiological and Molecular Plant Pathology, 1996, 49(3): 201-211.

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