Trifluoroacetophenone Chemical Properties

Melting point:

-40 °C

Boiling point:

165-166 °C (lit.) 46-48 °C/14 mmHg (lit.)

Density 

1.24 g/mL at 25 °C (lit.)

refractive index 

n20/D 1.458(lit.)

Flash point:

107 °F

storage temp. 

Sealed in dry,Room Temperature

solubility 

Chloroform, Ethyl Acetate

form 

Liquid

Specific Gravity

1.240

color 

Clear colorless to yellow

Water Solubility 

PRACTICALLY INSOLUBLE

BRN 

1866286

InChIKey

KZJRKRQSDZGHEC-UHFFFAOYSA-N

CAS DataBase Reference

434-45-7(CAS DataBase Reference)

NIST Chemistry Reference

Ethanone, 2,2,2-trifluoro-1-phenyl-(434-45-7)

EPA Substance Registry System

Ethanone, 2,2,2-trifluoro-1-phenyl- (434-45-7)

Safety Information

Hazard Codes 

Xi,F

Risk Statements 

10-36/37/38

Safety Statements 

26-36-37/39-16

RIDADR 

UN 1224 3/PG 3

WGK Germany 

3

Hazard Note 

Corrosive/Lachrymatory

TSCA 

T

HazardClass 

3

PackingGroup 

III

HS Code 

29147090

MSDS

• Language:English Provider:2,2,2-Trifluoroacetophenone
• Language:English Provider:ACROS
• Language:English Provider:SigmaAldrich
• Language:English Provider:ALFA

Trifluoroacetophenone Usage And Synthesis

Chemical Properties

CLEAR COLORLESS TO YELLOW LIQUID

Uses

2,2,2-Trifluoroacetophenone is a fluorinated acetophenone with inhibitory activity of acetylcholinesterase. 2,2,2-Trifluoroacetophenone was shown to have neuroprotective activity by inhibiting apoptos is in cerebellar granule neurons.

Uses

2,2,2-Trifluoroacetophenone is a fluorinated acetophenone with inhibitory activity of acetylcholinesterase. 2,2,2-Trifluoroacetophenone was shown to have neuroprotective activity by inhibiting apoptosis in cerebellar granule neurons.

General Description

2,2,2-Trifluoroacetophenone is the starting material for the synthesis of f 3-trifluoromethyl-3-phenyldiazirine. It undergoes asymmetric reduction with optically active Grignard reagent to form 2,2,2-trifluoro-1-phenylethanol. It undergoes condensation with biphenyl, terphenyl, a mixture of biphenyl with terphenyl, phenyl ether and diphenoxybenzophenone to form new aromatic 3F polymers.

Trifluoroacetophenone(434-45-7)Related Product Information

• 3'-Fluoroacetophenone
• 3-Aminoacetophenone
• 4'-Hydroxyacetophenone
• 4-Fluoroacetophenone
• 2',4'-Dichloroacetophenone
• Acetophenone
• 4-Nitroacetophenone
• 4'-Bromoacetophenone
• 2-Bromoacetophenone
• 3-Nitroacetophenone
• 4'-(Trifluoromethyl)acetophenone
• Trifluoroacetamide
• Trifluoroacetic acid
• Trifluoroacetic anhydride
• Trifluoroacetamidine
• Trifluoroacetyl chloride
• 4'-METHYL-2,2,2-TRIFLUOROACETOPHENONE
• 4-Carboxy-alpha,alpha,alpha-trifluoroacetophenone