Basic information Safety Supplier Related
ChemicalBook >  Product Catalog >  Biochemical Engineering >  Polypeptide >  Peptide 46

Peptide 46

Basic information Safety Supplier Related

Peptide 46 Basic information

Product Name:
Peptide 46
Synonyms:
  • PEPTIDE 46
  • P53 (361-382) (HUMAN)
  • p53 (361-382) (huMan), Cellular TuMor Antigen p53 (361-382) (huMan)
  • H-GLY-SER-ARG-ALA-HIS-SER-SER-HIS-LEU-LYS-SER-LYS-LYS-GLY-GLN-SER-THR-SER-ARG-HIS-LYS-LYS-OH
  • CELLULAR TUMOR ANTIGEN P53 (361-382) (HUMAN)
  • Glycyl-L-seryl-L-arginyl-L-alanyl-L-histidyl-L-seryl-L-seryl-L-histidyl-L-leucyl-L-lysyl-L-seryl-L-lysyl-L-lysylglycyl-L-glutaminyl-L-seryl-L-threonyl-L-seryl-L-arginyl-L-histidyl-L-lysyl-L-lysine
  • L-Lysine, glycyl-L-seryl-L-arginyl-L-alanyl-L-histidyl-L-seryl-L-seryl-L-histidyl-L-leucyl-L-lysyl-L-seryl-L-lysyl-L-lysylglycyl-L-glutaminyl-L-seryl-L-threonyl-L-seryl-L-arginyl-L-histidyl-L-lysyl-
CAS:
192122-40-0
MF:
C100H174N40O31
MW:
2432.7
Mol File:
192122-40-0.mol
More
Less

Peptide 46 Chemical Properties

Density 
1.56±0.1 g/cm3(Predicted)
storage temp. 
-15°C
InChIKey
KCXVFJXIDLDWKX-JEWKGGOJSA-N
More
Less

Peptide 46 Usage And Synthesis

Description

Peptide 46, a synthetic 22-mer peptide derived from the p53 C-terminal domain, can restore the growth suppressor function of mutant p53 proteins in human tumor cells. The sequence of peptide 46, which corresponds to residues 361 to 382 in the p53 C terminus, is (in one-letter code) GSRAHSSHLKSKKGQSTSRHKK[1]. Teptide 46, the only C-terminal peptide that can activate the specific DNA binding of p53, changed the mobility of the core domain, whereas the other C-terminal peptides did not. Conversely, the mobility of the C-terminal domain protein was shifted upon incubation with the core domain protein.

References

[1] G Selivanova. “Reactivation of mutant p53 through interaction of a C-terminal peptide with the core domain.” Molecular and Cellular Biology 19 5 (1999): 3395–402.

Peptide 46Supplier

GL Biochem (Shanghai) Ltd
Tel
21-61263452 13641803416
Email
ymbetter@glbiochem.com
Shanghai Hanhong Scientific Co.,Ltd.
Tel
021-54306202 13764082696
Email
info@hanhongsci.com
Chemsky (shanghai) International Co.,Ltd
Tel
021-50135380
Email
shchemsky@sina.com
Creative Peptides
Tel
Email
info@creative-peptides.com
Nanjing Leon Biological Technology Co., Ltd.
Tel
17705183659
Email
sales@njleonbiotech.com
More
Less

Peptide 46(192122-40-0)Related Product Information