Azadibenzocyclooctyne-PEG1-N-hydroxysuccinimidyl ester Chemical Properties

Density 

1.39±0.1 g/cm3(Predicted)

solubility 

Soluble in DMSO, DCM, DMF

form 

Solid

pka

15.12±0.46(Predicted)

color 

Off-white to light yellow

Azadibenzocyclooctyne-PEG1-N-hydroxysuccinimidyl ester Usage And Synthesis

Description

DBCO-PEG1-NHS Ester is a PEG containing molecule containing an NHS ester moiety that can react specifically and efficiently with primary amines (e.g. the side chain of lysine residues or aminosilane-coated surfaces) at neutral or slightly basic condition to form a covalent bond. DBCO is commonly used for copper-free Click Chemistry reactions.

Uses

DBCO-PEG1-NHS ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. DBCO-PEG1-NHS ester is a click chemistry reagent, it contains a DBCO group that can undergo strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing Azide groups.

IC 50

PEGs

References

[1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 DOI:10.1016/j.ebiom.2018.09.005

Azadibenzocyclooctyne-PEG1-N-hydroxysuccinimidyl ester(2228857-34-7)Related Product Information

• DBCO-PEG1-amine
• 5,8,11,14,17,20-Hexaoxa-2,23-diazaheptacosanoic acid, 27-(11,12-didehydrodibenz[b,f]azocin-5(6H)-yl)-24,27-dioxo-, 1,1-dimethylethyl ester
• DBCO-PEG3-CH2CO-NHS
• DBCO-PEG4-amine
• DBCO-PEG4-SE
• DBCO-NHS Ester
• DBCO-PEG2-NH-Boc
• DBCO-PEG4-DBCO
• DBCO-(CH2)2-NH2-CO-(CH2)3COOH-NHS
• DBCO-PEG3-acid
• Azadibenzocyclooctyne-Biotin conjugate
• 4,7,10,13-Tetraoxa-16-azaheneicosanoic acid, 21-(11,12-dihydrodibenz[b,f]azocin-5(6H)-yl)-17,21-dioxo-, 2,3,5,6-tetrafluorophenyl ester
• DBCO-NH-(CH2)4COOH
• DBCO-PEG3-amine
• DBCO-NH-Boc