1,2,3-Trimethoxybenzene Chemical Properties

Melting point:

43-47 °C (lit.)

Boiling point:

241 °C (lit.)

Density 

1.112 g/mL at 25 °C (lit.)

refractive index 

1.5470 (estimate)

Flash point:

>230 °F

storage temp. 

Sealed in dry,Room Temperature

solubility 

Chloroform (Slightly), DMSO (Slightly)

form 

Powder

color 

White to dark beige

Water Solubility 

Insoluble in water.

BRN 

1910422

InChI

1S/C9H12O3/c1-10-7-5-4-6-8(11-2)9(7)12-3/h4-6H,1-3H3

InChIKey

CRUILBNAQILVHZ-UHFFFAOYSA-N

SMILES

COc1cccc(OC)c1OC

LogP

1.530

CAS DataBase Reference

634-36-6(CAS DataBase Reference)

NIST Chemistry Reference

1,2,3-Trimethoxybenzene(634-36-6)

EPA Substance Registry System

Benzene, 1,2,3-trimethoxy- (634-36-6)

Safety Information

Risk Statements 

36/37/38

Safety Statements 

22-24/25

WGK Germany 

3

TSCA 

TSCA listed

HS Code 

29093090

Storage Class

11 - Combustible Solids

MSDS

• Language:English Provider:1,2,3-Trimethoxybenzene
• Language:English Provider:ACROS
• Language:English Provider:SigmaAldrich
• Language:English Provider:ALFA

1,2,3-Trimethoxybenzene Usage And Synthesis

Chemical Properties

WHITE TO DARK BEIGE POWDER

Uses

1,2,3-Trimethoxybenzene can be used for RSM-optimised slow pyrolysis of rice husk for bio-oil production.

Uses

1,2,3-Trimethoxybenzene was used to study the effect of solvent on photoinduced electron-transfer reactions.

Definition

ChEBI: A methoxybenzene that is benzene substituted by methoxy groups at positions 1, 2 and 3 respectively.

General Description

1,2,3-Trimethoxybenzene on condensation with 2,4-diamino-5-(hydroxymethyl)pyrimidine yields 2,4-diamino-5-(2,3,4-trimethoxybenzyl)pyrimidine.

Synthesis

Aqueous sodium hydroxide (40%，150 ml) is added dropwise during3-4 hr to a stirred mixture of pyrogallol (42 g，0.33 mole)，sodiumhydrosulphite (10 g,0.057 mole)，dimethyl sulphate (146 ml，194.60 g,1.54 mole) kept at 18-22°. Ice (1 kg) is then added and the reactionmixture left overnight. The separated solid is filtered and washed withwater. It is crystallised from methanol as colourless prisms. Yield 37.5 g(66.9%). M.p. 46-47°.Some more product (4 g, 7.1 %) is obtained byextraction of the mother liquor with ether (lit. m.p.46-47°).

Purification Methods

Sublime it under vacuum. [Beilstein 6 H 1081, 6 I 540, 6 II 1066, 6 III 6265, 6 IV 7329.]

1,2,3-Trimethoxybenzene(634-36-6)Related Product Information

• 4-Methoxyphenylacetic acid
• m-Anisyl alcohol
• 3-(METHOXYMETHOXY)BENZALDEHYDE
• p-Anisaldehyde
• (Trifluoromethoxy)benzene
• (3-Methoxyphenyl)acetonitrile
• Trimethyl phosphite
• o-Anisaldehyde
• Anisole
• Benzene
• Colchicine
• 3,4,5-Trimethoxybenzoyl chloride
• 2,3,4-Trimethoxybenzaldehyde
• 3,4,5-TRIMETHOXYCINNAMIC ACID
• 3,4,5-Trimethoxybenzonitrile
• 1,3,5-TRIMETHOXYBENZENE pure,sym-Trimethoxybenzene
• 3,4,5-Trimethoxy benzoic acid
• 1,4,5-Trimethoxybenzene,1,2,4-TRIMETHOXYBENZENE