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H2N-PEG4-CH2COOtBu

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H2N-PEG4-CH2COOtBu Basic information

Product Name:
H2N-PEG4-CH2COOtBu
Synonyms:
  • Amino-PEG4-CH2CO2tBu
  • NH2-PEG4-CH2COOtBu
  • H2N-PEG4-CH2COOtBu
  • tert-Butyl 14-amino-3,6,9,12-tetraoxatetradecanoate
  • 3,6,9,12-Tetraoxatetradecanoic acid, 14-amino-, 1,1-dimethylethylester
  • NH2-PEG4-CH2COOtB
  • Amino-PEG4-C1-Boc
  • tert-butyl14-amino-3,6,9,12-tetraoxatetradecan-1-oate
CAS:
864680-64-8
MF:
C14H29NO6
MW:
307.38
Product Categories:
  • peg
Mol File:
864680-64-8.mol
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H2N-PEG4-CH2COOtBu Chemical Properties

Boiling point:
386.1±32.0 °C(Predicted)
Density 
1.051±0.06 g/cm3(Predicted)
storage temp. 
-20°C, stored under nitrogen
solubility 
DMSO: 20 mg/mL (65.07 mM)
pka
8.74±0.10(Predicted)
form 
Liquid
color 
Colorless to light yellow
Water Solubility 
Water: 50 mg/mL (162.67 mM)
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H2N-PEG4-CH2COOtBu Usage And Synthesis

Uses

Amino-PEG4-C1-Boc is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

IC 50

PEGs

References

[1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 DOI:10.1016/j.ebiom.2018.09.005

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