Diethyl butylmalonate Chemical Properties

Melting point:

238 °C

Boiling point:

235-240 °C (lit.)

Density 

0.983 g/mL at 25 °C (lit.)

vapor pressure 

1Pa at 20℃

refractive index 

n20/D 1.422(lit.)

Flash point:

201 °F

storage temp. 

Sealed in dry,Room Temperature

solubility 

DMSO : 100 mg/mL (462.38 mM; Need ultrasonic)|

form 

clear liquid

pka

13.47±0.46(Predicted)

Specific Gravity

0.975 (20/4℃)

color 

Colorless to Almost colorless

Water Solubility 

330mg/L at 20℃

Merck 

14,1576

BRN 

608785

LogP

3.4 at 23℃

CAS DataBase Reference

133-08-4(CAS DataBase Reference)

NIST Chemistry Reference

Diethyl butylmalonate(133-08-4)

Safety Information

Safety Statements 

24/25

WGK Germany 

1

HS Code 

29171990

MSDS

• Language:English Provider:Diethyl n-butylmalonate
• Language:English Provider:SigmaAldrich
• Language:English Provider:ACROS
• Language:English Provider:ALFA

Diethyl butylmalonate Usage And Synthesis

Synthesis

Diethyl malonate is mixed with sodium ethoxide, and then chlorobutane is added to form the reaction. The crude product is separated and recovered ethanol, washed and dehydrated to obtain Diethyl butylmalonate.

Chemical Properties

CLEAR COLOURLESS LIQUID

Uses

Diethyl butylmalonate is used as a reagent in the synthesis of 2,5-dihydropyrrole formyl hydroxyamino derivatives as peptide deformylase inhibitors against drug-resistant bacteria.

Synthesis Reference(s)

Organic Syntheses, Coll. Vol. 1, p. 250, 1941
The Journal of Organic Chemistry, 44, p. 3492, 1979 DOI: 10.1021/jo01334a009

General Description

Diethyl malonate (DEM) undergoes alkylation by ethyliodide, which is used to study the phase transfer catalysis (PTC) technique.

Flammability and Explosibility

Not classified

Diethyl butylmalonate(133-08-4)Related Product Information

• Ethylene glycol diethyl ether
• Diethyl oxalate
• Diisopropyl malonate
• Mefenpyr-diethyl
• Diethyl methylmalonate
• Diethyl isopropylmalonate
• Diethyl bis(hydroxymethyl)malonate
• Diethyl benzylmalonate
• DIETHYL DIETHYLMALONATE
• Diethyl ketomalonate
• Diethyl allylmalonate
• Diethyl dipropylmalonate
• 2-AMINODIETHYLMALONATE
• Diethyl phenylmalonate
• Diethyl malonate
• DIETHYL DIMETHYLMALONATE
• Ethyl malonyl chloride
• N-(n-Butyl)thiophosphoric triamide