Naphazoline nitrate
Naphazoline nitrate Basic information
- Product Name:
- Naphazoline nitrate
- Synonyms:
-
- NAPHAZOLINE NITRATE
- NAPHAZOLINE NITRATE SALT
- NAPHAZOLINI NITRAS
- LABOTEST-BB LT00134653
- 2-(1-NAPHTHYLMETHYL)IMIDAZOLINIUM NITRATE
- 2-(1-NAPHTHYLMETHYL)IMIDAZOLINE NITRATE
- 2-[1-NAPHTHYLMETHYL]IMIDAZOLINE NITRATE SALT
- 2-(1-NAPHTHYLMETHYL)-2-IMIDAZOLINE NITRATE
- CAS:
- 5144-52-5
- MF:
- C14H15N3O3
- MW:
- 273.29
- EINECS:
- 225-915-4
- Product Categories:
-
- API
- Mol File:
- 5144-52-5.mol
Naphazoline nitrate Chemical Properties
- Melting point:
- 167-170 °C
- storage temp.
- 2-8°C
- solubility
- Sparingly soluble in water, soluble in ethanol (96 per cent).
- form
- Solid
- color
- White to off-white
- Sensitive
- Hygroscopic
- BRN
- 3779329
- InChI
- InChI=1S/C14H14N2.HNO3/c1-2-7-13-11(4-1)5-3-6-12(13)10-14-15-8-9-16-14;2-1(3)4/h1-7H,8-10H2,(H,15,16);(H,2,3,4)
- InChIKey
- ZAHXYMFVNNUHCP-UHFFFAOYSA-N
- SMILES
- C12C(C=CC=C1)=CC=CC=2CC1=NCCN1.[N+]([O-])(=O)O
- CAS DataBase Reference
- 5144-52-5(CAS DataBase Reference)
Safety Information
- Hazard Codes
- Xn
- Risk Statements
- 22
- Safety Statements
- 22-36/37-60-36
- RIDADR
- 3249
- WGK Germany
- 3
- RTECS
- NJ4376000
- F
- 3-10
- HazardClass
- 6.1(b)
- PackingGroup
- III
- HS Code
- 29332900
MSDS
- Language:English Provider:SigmaAldrich
- Language:English Provider:ALFA
Naphazoline nitrate Usage And Synthesis
Chemical Properties
White or almost white, crystalline powder.
Uses
antihistamine
Indications
Naphazoline hydrochloride and naphazoline nitrate are white or almost white crystalline powders soluble 1 in 6 and 1 in 36 water, respectively. These are potent sympathomimetic vasoconstrictors with a direct alpha-adrenergic receptor stimulatory action, and may be used as topical decongestants in 0.05% or 0.1% eyedrops. Frequent application of these solutions will produce a reactive hyperaemia. Instillation should not be repeated in less than 4-6 hours to avoid this rebound congestion.
Naphazoline eyedrops cause slight mydriasis and are contra-indicated in patients with actual or suspected closed-angle glaucoma.
Although not administered systemically, topical application of naphazoline has resulted in systemic absorption, and it is readily absorbed from the gastro-intestinal tract (Martindale, 1977).
Definition
ChEBI: Naphazoline nitrate is a member of naphthalenes.
in vivo
Naphazoline nitrate (0.2 mg/kg, 10 μl per eye; IP, once) reduces histamine or antigen-induced conjunctival vascular hyperpermeability in mice, and reduces conjunctivitis in mice via effects on inflammation, NGF and VEGF[1].
| Animal Model: | Female wild-type BALB/c mice (4-5 weeks, 18 ± 2 g, n=8/group, allergic conjunctivitis mouse model established using histamine or an antigen (ovalbumin))[1] |
| Dosage: | 0.2 mg/mL, 10 μl per eye |
| Administration: | Intraperitoneal injection (IP), once |
| Result: | Significantly suppressed conjunctival dye leakage in mice with histamine or antigen?induced conjunctival vascular hyperpermeability. Reduced inflammatory reactions and the levels of IL-1β, IL-6, IFN-γ, and IL-4. Reduced the levels of IgE, GMCSF, NGF and VEGF in antigen-induced conjunctival vascular hyperpermeability mice. |
IC 50
IL-1β; IL-6; IL-4
Naphazoline nitrate Preparation Products And Raw materials
Raw materials
Preparation Products
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Naphazoline nitrate (5144-52-5)Related Product Information
- Naphazoline hydrochloride
- Naphazoline
- Thiamine nitrate
- Miconazole Nitrate
- Imidazolidine
- Oxymetazoline
- Econazole nitrate
- Miconazole nitrate
- Sertaconazole nitrate
- Isoconazole nitrate
- NITRATE
- Potassium nitrate
- Ammonium nitrate
- Oxymetazoline hydrochloride
- 2-METHYL-2-IMIDAZOLINE
- Tolazoline
- Methylamine nitrate
- 1-ETHYLNAPHTHALENE