Naphazoline nitrate Chemical Properties

Melting point:

167-170 °C

solubility 

Sparingly soluble in water, soluble in ethanol (96 per cent).

form 

Solid

color 

White to off-white

Sensitive 

Hygroscopic

BRN 

3779329

InChIKey

ZAHXYMFVNNUHCP-UHFFFAOYSA-N

CAS DataBase Reference

5144-52-5(CAS DataBase Reference)

Safety Information

Hazard Codes 

Xn

Risk Statements 

22

Safety Statements 

22-36/37-60-36

RIDADR 

3249

WGK Germany 

3

RTECS 

NJ4376000

F 

3-10

HazardClass 

6.1(b)

PackingGroup 

III

HS Code 

29332900

MSDS

• Language:English Provider:SigmaAldrich
• Language:English Provider:ALFA

Naphazoline nitrate Usage And Synthesis

Chemical Properties

White or almost white, crystalline powder.

Uses

antihistamine

Indications

Naphazoline hydrochloride and naphazoline nitrate are white or almost white crystalline powders soluble 1 in 6 and 1 in 36 water, respectively. These are potent sympathomimetic vasoconstrictors with a direct alpha-adrenergic receptor stimulatory action, and may be used as topical decongestants in 0.05% or 0.1% eyedrops. Frequent application of these solutions will produce a reactive hyperaemia. Instillation should not be repeated in less than 4-6 hours to avoid this rebound congestion.
Naphazoline eyedrops cause slight mydriasis and are contra-indicated in patients with actual or suspected closed-angle glaucoma.
Although not administered systemically, topical application of naphazoline has resulted in systemic absorption, and it is readily absorbed from the gastro-intestinal tract (Martindale, 1977).

Definition

ChEBI: Naphazoline nitrate is a member of naphthalenes.

Naphazoline nitrate (5144-52-5)Related Product Information

• Naphazoline hydrochloride
• Naphazoline
• Thiamine nitrate
• Miconazole Nitrate
• Imidazolidine
• Oxymetazoline
• Econazole nitrate
• NITRATE
• Miconazole nitrate
• Sertaconazole nitrate
• Isoconazole nitrate
• Potassium nitrate
• Ammonium nitrate
• Oxymetazoline hydrochloride
• 2-METHYL-2-IMIDAZOLINE
• Tolazoline
• Methylamine nitrate
• 1-ETHYLNAPHTHALENE