BPV(HOPIC)
BPV(HOPIC) Basic information
- Product Name:
- BPV(HOPIC)
- Synonyms:
-
- BPV(HOPIC)
- DIPOTASSIUM BISPEROXO(5-HYDROXYPYRIDINE-2-CARBOXYL)OXOVANADATE (V)
- Bisperoxovanadium(HOpic)
- K2[VO(O2)2C6H4NO3]
- bpV(HOpic) (potassium salt)
- bpV(HOpic) (potassium salt, technical grade)
- MAPK/ERK,Phosphatase and tensin homolog,Inhibitor,PTEN,MMAC1,inhibit,PI3K/AKT,BpV(HOpic),signalling
- bpV(HOpic), PTP and PTEN inhibitor
- CAS:
- 722494-26-0
- MF:
- C6H4K2NO8V
- MW:
- 347.24
- Mol File:
- Mol File
BPV(HOPIC) Chemical Properties
- storage temp.
- -20°C
- solubility
- H2O: soluble20mg/mL, clear
- form
- powder
- color
- faint yellow to dark yellow
- Water Solubility
- water: 4mg/mL
BPV(HOPIC) Usage And Synthesis
Uses
bpV(HOpic) has been used in pharmacological perturbation of cell migration related signaling pathway.
Biochem/physiol Actions
bpV(OHpic) is a bisperoxovanadium inhibitor of protein phosphotyrosine phosphatases with selectivity for PTEN, phosphatase and tensin homolog, a tumour suppressor phosphatase involved in cell cycle regulation. IC50 values for bpV(HOpic) are 14 nM for PTEN compared to 4.9 μM for PTPβ and 25.3 μM for PTP-1β. bpV(HOpic) has been shown to enhance PI3K/Akt signaling that could prevent myocardium from ischemia-reperfusion injury.
in vivo
BpV(HOpic) (0.05 mg/kg; i.p.) at reperfusion ameliorates liver ischemia/reperfusion (I/R) injury in vivo[6].
BpV(HOpic) (200 μg/kg; i.p.) exacerbates renal dysfunction and promotes tubular damage in mice with ischemia/reperfusion injury (IRI)[7].
| Animal Model: | Male Wistar rats are subjected to partial hepatic ischemia[6] |
| Dosage: | 0.05 mg/kg |
| Administration: | I.p. injections at the start of reperfusion |
| Result: | Ameliorated reoxygenation injury and reproduced the hepatoprotective effects obtained by adenosine A2A receptor stimulation. |
| Animal Model: | Male C57BL/6 mice (8-12 weeks old; 20-30 g ) are subjected to renal ischemia[7] |
| Dosage: | 200?μg/kg |
| Administration: | I.p. injections 1?h before ischemia and then administers every 6?h after ischemia for 24 hr |
| Result: | Raised the level of serum creatinine and blood serum urea nitrogen. |
BPV(HOPIC)Supplier
- Tel
- 1-631-485-4226; 16314854226
- info@bocsci.com
- Tel
- 020-39119399 18927568969
- isunpharm@qq.com
- Tel
- 021-61415566 800-8193336
- orderCN@merckgroup.com
- Tel
- 16314854226
- info@bocsci.com
- Tel
- 021-65675885 18964387627
- info@efebio.com