TRICYCLOHEXYLPHOSPHONIUM TETRAFLUOROBORATE Chemical Properties

Melting point:

164 °C(lit.)

storage temp. 

Keep in dark place,Sealed in dry,Room Temperature

solubility 

Dichloromethane (Slightly), Methanol (Slightly)

form 

Powder

color 

White

Water Solubility 

Soluble in water.

InChIKey

KZGFMSRKDNYVKL-UHFFFAOYSA-N

Safety Information

Risk Statements 

36/37/38

Safety Statements 

22-24/25

RIDADR 

1759

WGK Germany 

3

TSCA 

No

HazardClass 

8

PackingGroup 

III

HS Code 

29209090

MSDS

• Language:English Provider:SigmaAldrich

TRICYCLOHEXYLPHOSPHONIUM TETRAFLUOROBORATE Usage And Synthesis

Reactions

Non-pyrophoric, air-stable derivative suitable as a replacement for the neat phosphine in a variety of stoichiometric and catalytic processes.

Chemical Properties

White powder

Uses

suzuki reaction

Uses

Tricyclohexylphosphonium Tetrafluoroborate acts as a reagent in the synthesis of potent JAK2 inhibitor BMS-911543 as a potential treatment for myeloproliferative disorders, preparation of Lapatinib intermediate via arylation of furfural with bromochlorofluorobenzyloxyphenylquinazolinamine, structure-activity relationships of carboline and carbazole derivatives as ATP-competitive kinesin spindle protein inhibitors.

Uses

Tricyclohexylphosphine tetrafluoroborate may be used in the following processes:

• As a ligand for preparing C-homoaporphine alkaloids via microwave-assisted direct-arylation.
• To synthesize poly-[9,9-bis(3-propylamide-2-methylpropyl sulfonic acid) fluorene]-co-(4,4′-diphenyl) (PFDBSO₃H), which can be employed as a template and doping agent for enhancing the conductivity of poly(3,4-ethylenedioxythiophene) (PEDOT) films.
• To improve the reactivity of palladium-catalyzed Suzuki-Miyaura cross-coupling reaction between MIDA boronates and less activated alkenyl tosylates.

General Description

Tricyclohexylphosphine tetrafluoroborate (PCy₃·HBF₄) is an inexpensive and air-stable phosphine ligand, commonly used in cross-coupling reactions.

TRICYCLOHEXYLPHOSPHONIUM TETRAFLUOROBORATE(58656-04-5)Related Product Information

• Tricyclohexyl phosphine
• Trimethylsilyl 2-(fluorosulfonyl)difluoroacetate
• O-(2,2,2-Trifluoroethyl)hydroxylamine hydrochloride
• 1,3-Bis(diphenylphosphino)propane
• Dichloromethane
• N,N-Dimethylacetamide
• Lithium bis(trimethylsilyl)amide
• Palladium (II) Acetate
• Tri-tert-butylphosphine
• TRIS(1-PYRROLIDINYL)PHOSPHINE 97
• TRICYCLOPENTYLPHOSPHINE
• Tri-tert-butylphosphine tetrafluoroborate
• N,N'-Dimethyl-1,2-ethanediamine
• CYCLOHEXYLPHOSPHINE
• TRI-N-BUTYLPHOSPHONIUM TETRAFLUOROBORATE
• TRICYCLOHEXYLPHOSPHONIUM TETRAFLUOROBORATE
• BORANE-DICYCLOHEXYLPHOSPHINE COMPLEX
• TRIISOPROPYLPHOSPHONIUM TETRAFLUOROBORATE