2,2-Diethoxyethanol Chemical Properties

Boiling point:

166-167°C

Density 

0.9000

refractive index 

1.4160

Flash point:

62°C

storage temp. 

under inert gas (nitrogen or Argon) at 2-8°C

solubility 

Chloroform (Slightly), Ethyl Acetate, Methanol (Slightly)

form 

Oil

pka

14.83±0.10(Predicted)

color 

Clear Colourless

Water Solubility 

Miscible with water, chloroform and ethyl acetate.

BRN 

773727

InChI

InChI=1S/C6H14O3/c1-3-8-6(5-7)9-4-2/h6-7H,3-5H2,1-2H3

InChIKey

IKKUKDZKIIIKJK-UHFFFAOYSA-N

SMILES

C(O)C(OCC)OCC

LogP

0.656 (est)

CAS DataBase Reference

621-63-6(CAS DataBase Reference)

Safety Information

Safety Statements 

23-24/25

HS Code 

2911000000

MSDS

• Language:English Provider:2,2-Diethoxyethanol
• Language:English Provider:ALFA

2,2-Diethoxyethanol Usage And Synthesis

Uses

2,2-Diethoxyethanol is used in the synthesis of neooxazolomycin, part of the oxazolomycin family of antibiotics. Also used in the synthesis of pyrimidine based inhibitors of phosphodiesterase 7 (PDE7).

Synthesis

The general procedure for the synthesis of 2,2-diethoxyethanol from ethyl 2,2-diethoxyacetate was as follows: 302.6 g (8 mol) of sodium borohydride was slowly added to 2 L of 1,2-dimethoxyethane (monoglycol dimethyl ether) under stirring conditions. Subsequently, 704.8 g (4 mol) of ethyl 2,2-diethoxyacetate solution dissolved in 4 L of ethanol was added dropwise, and the dropwise acceleration was controlled to maintain the reaction temperature below 50 °C, a process that took about 4 hours. After completion of the titration, the reaction mixture was heated to reflux for 3 hours. Upon completion of the reaction, about 2 L of ethanol was removed by distillation, followed by the slow dropwise addition of 4 L of water, while residual ethanol was removed by azeotropic distillation. During the dropwise addition, a large amount of precipitate was observed to be generated, but the precipitate gradually dissolved with continued addition of water. Next, 1,2-dimethoxyethane was added to the reaction mixture and the mixture was cooled in an ice bath. Under stirring, 600 g of potassium carbonate was added to the cooled mixture. Subsequently, the mixture was extracted with 2 L of ether and the organic phases were combined and dried with anhydrous magnesium sulfate. After drying, the ether was removed by evaporation to give the crude product. The crude product was purified by vacuum distillation and the fractions with boiling points of 75-76 °C (15 mmHg) were collected to give 475.8 g of the target product 2,2-diethoxyethanol in 88.7% yield. The product was analyzed by elemental analysis (calculated values: C 53.7%, H 10.5%; measured values: C 53.11%, H 10.57%) and IR spectroscopy (3441 cm^-1; 2976 cm^-1; 2931 cm^-1; 2883 cm^-1; 1445 cm^-1; 1374 cm^-1; 1345 cm^-1; 1235 cm^- 1; 1134 cm^-1; 1073 cm^-1, KBr compression method) characterization confirmed.

References

[1] Patent: EP1030841, 2004, B1. Location in patent: Page 11

2,2-Diethoxyethanol(621-63-6)Related Product Information

• DIETHOXYMETHANE
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• 2-(2-Chloroethoxy)ethanol
• 2-Ethoxyethanol
• Ethoxyquin
• G-STROPHANTHIN
• MALTOTRIOSE
• Maltitol
• DIACETONE-D-GLUCOSE
• STACHYOSE
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• D-(+)-MELEZITOSE
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