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Coumarin 120

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Coumarin 120 Basic information

Product Name:
Coumarin 120
Synonyms:
  • 7-Amino-4-methyl-2H-chromen-2-one, 7-Amino-4-methyl-2-oxo-2H-chromene, 7-Amino-4-methyl-2-oxo-2H-1-benzopyran
  • Coumarin 120, AMC
  • (2S,5R,6R)-6-[(2R)-2-aMino-2-(4-hydroxyphenyl)acetaMido]-3,3-diMethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid
  • 7-AMino-4-MethylcouMarin 
  • 7-AMino-4-MethylcouMarin, pure, 98% 1GR
  • 7-AMino-4-MethylcouMarin 99%
  • 7-Amino-4-methylcoumarin≥ 98% (HPLC)
  • AMC [7-Amino-4-methylcoumarin] *CAS 26093-31-2*
CAS:
26093-31-2
MF:
C10H9NO2
MW:
175.18
EINECS:
247-454-8
Product Categories:
  • Building block
  • Peptide
  • Coumarins
  • Other Reagents
  • Labeling and Diagnostics Reagents
Mol File:
26093-31-2.mol
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Coumarin 120 Chemical Properties

Melting point:
223-226 °C (lit.)
Boiling point:
306.47°C (rough estimate)
Density 
1.1999 (rough estimate)
refractive index 
1.5060 (estimate)
storage temp. 
2-8°C
solubility 
Soluble in acetone (10 mg/ml) dimethyl sulfoxide (10 mg/ml) and dimethylformamide.
form 
Crystalline Powder
pka
1.89 ± 0.20, most basic, temperature: 25 °C
color 
Beige to brown
Sensitive 
Light Sensitive
λmax
351 nm (MeOH); 342 nm (Buffer pH 7)
BRN 
142231
Major Application
For authentification; dyelasers; color display devices; inks;monitoring underlying corrosion on coated aluminum;photoinitiating systems; recording materials;semiconductor devices; dye-sensitized solar cells(DSCs); mesoporous silica fibers; SiO2 sonogelhybrid materials; textiles; waveguides;whitening agents,
Biological Applications
Identifyingbacteria; measuring urinary kallikrein levels;monitoring platinum(iv) reduction and platinum(ii)reactions in cancer cells; as a substrate for measuringadipinylamidases activity, aromatic amino aciddecarboxylases activity, histone deacetylasesactivity, hydrolases/esterases activity,β-lactamases activity, microbial nitroreductasesactivity, penicillin G acylases activity,proteases/proteinases/peptidases activity,glutamyltransferases activity, tryptophanasesactivity; as an effective antitubercular agent; use astemperature sensor,
InChIKey
GLNDAGDHSLMOKX-UHFFFAOYSA-N
CAS DataBase Reference
26093-31-2(CAS DataBase Reference)
NIST Chemistry Reference
Coumarin, 7-amino-4-methyl-(26093-31-2)
EPA Substance Registry System
2H-1-Benzopyran-2-one, 7-amino-4-methyl- (26093-31-2)
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Safety Information

Hazard Codes 
Xi,Xn
Risk Statements 
36/37/38-20/21/22
Safety Statements 
26-36-37/39
WGK Germany 
3
Hazard Note 
Irritant
TSCA 
Yes
HS Code 
32049000

MSDS

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Coumarin 120 Usage And Synthesis

Chemical Properties

Coumarin 120 is Light yellow beige powder

Uses

Coumarin 120 is widely used fluorophore, well-known for preparing fluorogenic substrates for cystine aminopeptidase and other hydrolases. Used as reference compound in enzyme assays.

Uses

suitable for determining polygalacturonase activity

Uses

λ max 354 nm in EthanolSuitable as laser dye and used as a fluorescent labeling reagent for trace determination of enzymes.

Definition

ChEBI: Coumarin 120 is a member of 7-aminocoumarins. It has a role as a fluorochrome.

General Description

7-Amino-4-methylcoumarin (coumarin120) is an aminocoumarin laser dye that can emit laser in the range of 370-760 nm. It has three intermolecular hydrogen bonded structures with C-H···O and N-H····O.

Biochem/physiol Actions

7-Amino-4-methylcoumarin is a coumarin derivative, which serves as a fluorescence reference standard to screen protease inhibitors.

storage

+4°C

Purification Methods

Dissolve it in 5% HCl, filter and basify with 2M ammonia. The precipitate is dried in a vacuum and recrystallised from dilute EtOH. It yields a blue solution and is light sensitive. [Sigler Synthesis 614 1980, Kanaoka et al. Chem Pharm Bull Jpn 30 1485 1982, Beilstein 18/11 V 445.]

Coumarin 120Supplier

Chongqing AoShe Biological Chemical Co., Ltd. Gold
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