N-Methyl-N-(trimethylsilyl)acetamide Chemical Properties

Boiling point:

159-161 °C(lit.)

Density 

0.904 g/mL at 20 °C(lit.)

refractive index 

n20/D 1.439

Flash point:

48 °C

storage temp. 

-20°C

form 

lyophilized powder

pka

-0.11±0.70(Predicted)

color 

Clear light yellow

Specific Gravity

0.906

Sensitive 

Moisture Sensitive

BRN 

506975

CAS DataBase Reference

7449-74-3(CAS DataBase Reference)

NIST Chemistry Reference

Acetamide, n-methyl-n-(trimethylsilyl)-(7449-74-3)

EPA Substance Registry System

Acetamide, N-methyl-N-(trimethylsilyl)- (7449-74-3)

Safety Information

Hazard Codes 

Xi

Risk Statements 

10-36/37/38

Safety Statements 

37/39-16

RIDADR 

UN 1993 3/PG 3

WGK Germany 

3

F 

10-21

TSCA 

Yes

HazardClass 

3

PackingGroup 

III

HS Code 

29319090

MSDS

• Language:English Provider:ACROS
• Language:English Provider:SigmaAldrich
• Language:English Provider:ALFA

N-Methyl-N-(trimethylsilyl)acetamide Usage And Synthesis

Chemical Properties

clear light yellow liquid

Uses

N-Methyl-N-trimethylsilylacetamide may be used as a derivatizing reagent for the following:???????

• Quantification of the carbohydrate intermediates in glycation systems using gas chromatography coupled to mass spectrometry technique.???????
• Characterization of damaged products of thymine and cytosine formed by the exposure to UV light in a hydrogen peroxide solution using gas chromatography/mass spectrometry with scan mode and selected ion monitoring mode.

General Description

N-Methyl-N-trimethylsilylacetamide is a trialkyl-silyl reagent and a versatile derivatizing agent used in gas chromatography (GC).

Purification Methods

N-Methyl-N-trimethylsilylacetamide [7449-74-3] M 145.3, b 48 -49o/11mm, 8 4o/13mm, 105-107o/35mm (solid at room temperature), d 4 0.90, n D 1.4379. A likely impurity is Et3N.HCl which can be detected by its odour. If it is completely soluble in *C6H6, then redistil; otherwise dissolve it in this solvent, filter and evaporate first in a vacuum at 12mm, then fractionate; all operations should be carried out in a dry N2 atmosphere. [Klebe et al. J Am Chem Soc 88 3390 1966, Ried & Suarez-Rivero Chem Ber 96 1473 1963, Beilstein 4 IV 4011.]

N-Methyl-N-(trimethylsilyl)acetamide(7449-74-3)Related Product Information

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