2,3,5-TRIFLUOROANILINE Chemical Properties

Boiling point:

175℃

Density 

1.409

Flash point:

69℃

refractive index 

1.4895

storage temp. 

Keep in dark place,Inert atmosphere,Room temperature

pka

1.18±0.10(Predicted)

form 

liquid

color 

Clear, faint brown

Specific Gravity

1.390

CAS DataBase Reference

363-80-4(CAS DataBase Reference)

Safety Information

Hazard Codes 

Xi

Risk Statements 

20/21/22-36/37/38

Safety Statements 

26-36/37/39

RIDADR 

UN2810

Hazard Note 

Irritant

HazardClass 

6.1

HS Code 

2921420090

2,3,5-TRIFLUOROANILINE Usage And Synthesis

Synthesis

The general procedure for the synthesis of 2,3,5-trifluoroaniline from aniline was as follows: 9.3 g (0.1 mol) of aniline was dissolved in 50 mL of glacial acetic acid, cooled to 10 °C, and then 8.2 g (0.12 mol) of sodium nitrite was slowly added. Subsequently, a solution prepared from 33 g (0.3 mol) sodium borohydride dissolved in 50 mL of water was added slowly and dropwise at the same temperature. After completion of the reaction, the product was separated by filtration. The filtrate was extracted by adding 100 mL of ethyl acetate to the filtrate and this operation was repeated three times. The organic phases were combined and washed sequentially with 10 mL of aqueous sodium fluoroborate and 50 mL of pure water. Finally, the organic phase was evaporated to dryness to give 9 g of 2,3,5-trifluoroaniline.

References

[1] Patent: CN107522609, 2017, A. Location in patent: Paragraph 0015; 0018; 0019
[2] Patent: CN107673951, 2018, A. Location in patent: Paragraph 0013

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