DL-alpha-Methylbenzylamine Chemical Properties

Melting point:

-65 °C

Boiling point:

185 °C756 mm Hg(lit.)

Density 

0.94 g/mL at 25 °C(lit.)

vapor pressure 

0.7 hPa (20 °C)

refractive index 

n20/D 1.526(lit.)

Flash point:

175 °F

storage temp. 

Store below +30°C.

solubility 

42g/l

form 

Liquid

pka

9.04±0.10(Predicted)

color 

Clear colorless to light yellow

Water Solubility 

4.2 g/100 mL (20 ºC)

Sensitive 

Air Sensitive

Merck 

14,6026

BRN 

636127

Dielectric constant

4.4（18℃）

Stability:

Stable, but absorbs carbon dioxide from the air. Store under an inert atmosphere. Incompatible with strong oxidizing agents, carbon dioxide.

InChIKey

RQEUFEKYXDPUSK-UHFFFAOYSA-N

LogP

1.31 at 25℃

CAS DataBase Reference

618-36-0(CAS DataBase Reference)

NIST Chemistry Reference

Benzenemethanamine, «alpha»-methyl-, (.+/-.)-(618-36-0)

EPA Substance Registry System

Benzenemethanamine, .alpha.-methyl- (618-36-0)

Safety Information

Hazard Codes 

C

Risk Statements 

21/22-34

Safety Statements 

26-28-36/37/39-45-28A

RIDADR 

UN 2735 8/PG 2

WGK Germany 

1

RTECS 

DP5775000

F 

10-23

Autoignition Temperature

355 °C

TSCA 

Yes

HazardClass 

8

PackingGroup 

III

HS Code 

29214980

MSDS

• Language:English Provider:DL-alpha-Methylbenzylamine
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DL-alpha-Methylbenzylamine Usage And Synthesis

Chemical Properties

liquid

Uses

Used for synthesis and as an emulsifying agent; used as a resolving agent and chiral intermediate.

Uses

α-Methylbenzylamine can be used as a reactant for the synthesis of dihydro-5H-dibenz[c,e]azepinium salts by reacting with racemic biphenol derivatives.

Definition

ChEBI: A phenylethylamine that is ethylamine substituted by a phenyl group at position 1.

Synthesis Reference(s)

The Journal of Organic Chemistry, 49, p. 4272, 1984 DOI: 10.1021/jo00196a031
Chemical and Pharmaceutical Bulletin, 36, p. 1529, 1988 DOI: 10.1248/cpb.36.1529
Tetrahedron Letters, 27, p. 3957, 1986 DOI: 10.1016/S0040-4039(00)84883-2

General Description

α-Methylbenzylamine is a nitrogen source that is widely used as a representative substrate to study the chemo-enzymatic kinetic resolution of primary amines.

Flammability and Explosibility

Non flammable

Purification Methods

Dissolve the amine in toluene, dry over NaOH and distil; fraction boiling at 187-188o/atm is collected. Store it under N2 to avoid forming the carbamate and urea. Similarly for the S-(-) enantiomer [2627-86-3]. [Ingersoll Org Synth Coll Vol II 503 1943, Robinson & Snyder Org Synth Coll Vol III 717 1955, Beilstein 12 IV 2424, 2425.]

DL-alpha-Methylbenzylamine(618-36-0)Related Product Information

• DL-ALPHA-METHYLBENZYLAMINE
• Phenoxybenzamine hydrochloride
• Diethylstilbestrol
• Tyramine
• 2-Phenylethylamine hydrochloride
• Trimethoprim
• 4-Fluorobenzylamine
• (R)-(+)-1-Phenylethylamine
• 2-Hexenamide, 2-cyano-5-methyl-
• Hexanoic acid,3-(aminomethyl)-5-methyl-, (3R)-
• 2,4-Dicyano-3-(2-Methylpropyl)-pentanediaMide
• 3-((methoxycarbonyl)methyl)-5-methylhexanoic acid
• 4,9-diisobutyl-1,6-diazecane-2,7-dione
• Isovaleraldehyde
• Pregabalin Impurity PD0224377
• Pregabalin Impurity 49
• 4-Isobutyl-2-pyrrolidinone
• (S)-Pregabalin Methyl Ester