Glycinamide hydrochloride Chemical Properties

Melting point:

204 °C (dec.)(lit.)

storage temp. 

Inert atmosphere,Room Temperature

solubility 

H₂O: 0.1 g/mL, clear

form 

Crystalline Powder

color 

White to beige

pka

8.20(at 20℃)

Water Solubility 

Soluble in water (1100g/L).

Sensitive 

Hygroscopic

λmax

λ: 260 nm Amax: 0.1

BRN 

3554199

Stability:

Hygroscopic

InChIKey

WKNMKGVLOWGGOU-UHFFFAOYSA-N

CAS DataBase Reference

1668-10-6(CAS DataBase Reference)

Safety Information

Hazard Codes 

Xi

Risk Statements 

36/37/38

Safety Statements 

22-24/25-37/39-26

WGK Germany 

3

F 

3-10

HazardClass 

IRRITANT

HS Code 

29241900

MSDS

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Glycinamide hydrochloride Usage And Synthesis

Chemical Properties

Crystalline

Uses

Glycinamide hydrochloride is a buffer that is useful in the physiological pH range. And it is also used as a pharmaceutical intermediate, in the organic synthesis.

Uses

Glycinamide hydrochloride may be used in the synthesis of [M(glycinamidato-N,N′)(ptpy)₂] where ptpy = 2-(p-tolyl)pyridinato) and M= Rh or Ir.
It may be used in the synthesis of the following glycinamide-based imidazolidinones:

• (±)-2-(2-phenylpropyl)imidazolidin-4-one
• (±)-2-(2,4,4-trimethylpentyl)imidazolidin-4-one
• (±)-2-[(R)-2,6-dimethyl-5-heptenyl]imidazolidin-4-one
• (5R,6S,9R)-6-isopropyl-9-methyl-1,4-diazaspiro[4.5]decan-2-one
• (5S,6S,9R)-6-isopropyl-9-methyl-1,4-diazaspiro[4.5]decan-2-one
• (±)-2-methyl-2-pentylimidazolidin-4-one
• (±)-2-ethyl-2-(2-methylbutyl)imidazolidin-4-one
• (±)-2-(undecan-2-yl)imidazolidin-4-one
• (±)-2-pentylimidazolidin-4-one
• 2-(2,4-dimethylcyclohex-3-en-1-yl)imidazolidin-4-one

Purification Methods

Crystallise the salt from EtOH, EtOH/H2O or MeOH. [Karmas & Spoerri J Am Chem Soc 74 1580 1952, Beilstein 4 IV 2358.]

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