2,5-Hexanediol Chemical Properties

Melting point:

43°C

Boiling point:

216-218 °C (lit.)

Density 

0.961 g/mL at 25 °C (lit.)

refractive index 

n20/D 1.447(lit.)

Flash point:

215 °F

storage temp. 

2-8°C

pka

14.87±0.20(Predicted)

form 

clear liquid

color 

Colorless to Light orange to Yellow

Water Solubility 

Soluble

BRN 

1719248

LogP

-0.060 (est)

CAS DataBase Reference

2935-44-6(CAS DataBase Reference)

NIST Chemistry Reference

2,5-Hexanediol(2935-44-6)

EPA Substance Registry System

2,5-Hexanediol (2935-44-6)

Safety Information

Hazard Codes 

Xn

Risk Statements 

22-36/37/38

Safety Statements 

26-36-37/39

WGK Germany 

3

RTECS 

MO2275000

TSCA 

Yes

HS Code 

29053990

MSDS

• Language:English Provider:ACROS
• Language:English Provider:SigmaAldrich
• Language:English Provider:ALFA

2,5-Hexanediol Usage And Synthesis

Description

2,5-Hexanediol is an alcohol compound with hydroxyl functional groups that can be used in the synthesis of polyesters.

Chemical Properties

clear colorless to light yellow viscous liquid

Uses

2,5-Hexanediol is used as an organic chemical synthesis intermediate.

Definition

ChEBI: Hexane-2,5-diol is a glycol that is hexane substituted by hydroxy groups at positions 2 and 5. It is a glycol and a secondary alcohol. It derives from a hydride of a hexane.

Toxicity evaluation

2,5-Hexanediol is a metabolite of hexane, the chronic toxicity of which is attributed to hexane-2,5-dione and which causes polyneuropathy in humans following long-term exposure. Oral administration of 2,5-Hexanediol to rats also showed signs of central and peripheral neuropathy, weakness and even paralysis of the hind limbs. It also impairs immunocompetence in mice, as evidenced by reduced lymphoid organ weights, histological abnormalities in the thymus, spleen and adrenal glands, cytopenia of lymphoid organs and reduced resistance to endotoxic shock^[1~3].

References

[1] S K GOEL; C R K; G S Rao. Toxicity of n-hexane and 2,5-hexanediol to the haemopoietic system: a preliminary report.[J]. Xenobiotica, 1987, 17 2: 217-222. DOI:10.3109/00498258709043931.
[2] K. KANNAN . Effect of 2,5-hexanediol on immunocompetence of mice[J]. Environmental Research, 1985, 36 1: Pages 14-25. DOI:10.1016/0013-9351(85)90003-9.
[3] ANNELIESE EBEN. Toxicological and metabolic studies of methyl n-butylketone, 2,5-hexanedione, and 2,5-hexanediol in male rats[J]. Ecotoxicology and Environmental Safety, 1979, 3 2: Pages 204-217. DOI:10.1016/0147-6513(79)90012-5.

2,5-Hexanediol(2935-44-6)Related Product Information

• Methylcyclohexane
• Cyclohexane
• 2-Methyl-2,4-pentanediol
• Hexane
• 1,6-Hexanediol
• Cyclohexene oxide
• 1,2-Hexanediol
• POLY(1 6-HEXAMETHYLENE ADIPATE) AVERAG&
• Hyodeoxycholic acid
• 1,2:5,6-Bis-O-(1-methylethylidene)-D-mannitol
• Quinic acid
• 1,4-HEXANEDIOL,1,4-HEXANEDIOL
• TRANS-1,2-CYCLOHEXANEDIOL
• G-STROPHANTHIN
• MUCIC ACID
• D-GLUCOSE DIETHYL MERCAPTAL
• Gluconic acid
• Chlorogenic acid