2-(3,4-dichlorophenyl)-N-[4-(1,2-oxazol-3-ylsulfamoyl)phenyl]acetamide Chemical Properties

storage temp. 

Store at -20°C

solubility 

DMSO : 250 mg/mL (586.48 mM; Need ultrasonic)

2-(3,4-dichlorophenyl)-N-[4-(1,2-oxazol-3-ylsulfamoyl)phenyl]acetamide Usage And Synthesis

Biological Activity

ML251, a potent nanomolar T. brucei and T. cruzi phosphofructokinase (PFK) inhibitor, inhibits T. brucei PFK (IC50=0.37 μM) and T. cruzi PFK (IC50=0.13 μM). ML251 can be used for the research of parasite[1]. ML251 (T. brucei; 0~33.3 μg/mL) produces modest dose-dependent toxicity[1].

References

[1]. Brimacombe KR, et al. Identification of ML251, a Potent Inhibitor of T. brucei and T. cruzi Phosphofructokinase. ACS Med Chem Lett. 2013;5(1):12-17.

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