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MELITTIN

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MELITTIN Basic information

Product Name:
MELITTIN
Synonyms:
  • beevenommelittin
  • forapin
  • forapine
  • Gly-L-Ile-Gly-L-Ala-L-Val-L-Leu-L-Lys-L-Val-L-Leu-L-Thr-L-Thr-Gly-L-Leu-L-Pro-L-Ala-L-Leu-L-Ile-L-Ser-L-Trp-L-Ile-L-Lys-L-Arg-L-Lys-L-Arg-L-Gln-L-Gln-NH2
  • Gly-L-Ile-Gly-L-Ala-L-Val-L-Leu-L-Lys-L-Val-L-Leu-L-Thr-L-Thr-Gly-L-Leu-L-Pro-L-Ala-L-Leu-L-Ile-L-Ser-L-Trp-L-Ile-L-Lys-L-Arg-L-Lys-L-Arg-L-Glu(NH2)-L-Glu(NH2)-NH2
  • GLY-ILE-GLY-ALA-VAL-LEU-LYS-VAL-LEU-THR-THR-GLY-LEU-PRO-ALA-LEU-ILE-SER-TRP-ILE-LYS-ARG-LYS-ARG-GLN-GLN-NH2: GIGAVLKVLTTGLPALISWIKRKRQQ-NH2
  • C11198
  • melittin from honey bee venom
CAS:
20449-79-0
MF:
C131H229N39O31
MW:
2846.46
EINECS:
629-303-1
Product Categories:
  • Amino Acids
  • Calcium Antagonists
  • Cell Signaling and Neuroscience
  • Intracellular Calcium Signaling
Mol File:
20449-79-0.mol
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MELITTIN Chemical Properties

alpha 
D21 -89.52° (c = 0.409)
Density 
1.39
storage temp. 
-20°C
solubility 
Soluble to 1 mg/ml in 20% acetonitrile
form 
White to faint tan powder.
color 
White to off-white
Water Solubility 
Soluble to 1 mg/ml in water
Sequence
H-Gly-Ile-Gly-Ala-Val-Leu-Lys-Val-Leu-Thr-Thr-Gly-Leu-Pro-Ala-Leu-Ile-Ser-Trp-Ile-Lys-Arg-Lys-Arg-Gln-Gln-NH2
InChIKey
VDXZNPDIRNWWCW-JFTDCZMZSA-N
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Safety Information

Hazard Codes 
T
Risk Statements 
23/24/25
Safety Statements 
36-45-36/37/39
RIDADR 
UN 3462 6.1/PG 1
WGK Germany 
3
RTECS 
OS3965000
F 
10-21

MSDS

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MELITTIN Usage And Synthesis

Uses

Melittin has been used in standard bacterium-killing assay to determine bactericidal activity and study the role of melittin in allergic reactions.

Uses

Melittin from honey bee venom has been used:

  • In 3-(4, 5-dimethyl thiazol-2-yl)-2,5diphenyl tetrazolium bromide (MTT) assay to determine its cytotoxicity effect on the growth of human cell lines.
  • To study the anti-microbial activity of melittin on the growth of Borrelia burgdorferi in in vitro conditions.
  • As a positive control in hemolysis assay and as a cytotoxic agent against HeLa cells.

Definition

ChEBI: A 26-membered polypeptide consisting of Gly, Ile, Gly, Ala, Val, Leu, Lys, Val, Leu, Thr, Thr, Gly, Leu, Pro, Ala, Leu, Ile, Ser, Trp, Ile, Lys, Arg, Lys, Arg, Gln and Gln-NH2 residues joined in sequence. It is the principal active com onent of bee venom.

General Description

Chemical structure: peptide

Biochem/physiol Actions

Melittin acts as an anti-coagulating protein by increasing the time of blood clotting in vitro. Melittin inhibits the activity of S100 calcium-binding protein B (S100B) and plays a vital role in Epilepsy treatment. Melittin retard cathepsin S-induced invasion, proliferation and angiogenesis via inhibition of the vascular endothelial growth factor A (VEGF-A) /VEGF receptor 2 (VEGFR-2)/ mitogen-activated protein kinase 1 (MEK1)/ extracellular signal-regulated kinase 1/2 (ERK1/2) pathway in human MHCC97-H cells (liver cancer cells). Melittin has therapeutic application in various inflammatory diseases such as skin inflammation, neuroinflammation, atherosclerosis, arthritis and liver inflammation. Accumulated melittin degrades phospholipid packing in the cell membrane and causes cell lysis and cell death.

storage

Store at -20°C

MELITTINSupplier

3B Pharmachem (Wuhan) International Co.,Ltd.
Tel
821-50328103-801 18930552037
Email
3bsc@sina.com
GL Biochem (Shanghai) Ltd
Tel
21-61263452 13641803416
Email
ymbetter@glbiochem.com
Shanghai Hanhong Scientific Co.,Ltd.
Tel
021-54306202 13764082696
Email
info@hanhongsci.com
Chemsky (shanghai) International Co.,Ltd
Tel
021-50135380
Email
shchemsky@sina.com
Cellmano Biotech Limited
Tel
0551-65326643 18156095617
Email
info@cellmano.com
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